Evidence map›Paper›PMID 41422247›Full record

ArticleNutrition journal2025

Dietary nitrosyl-heme from processed meats and its association with colorectal cancer risk: findings from the EPIC cohort study.

Lucía Rizzolo-Brime, Leila Lujan-Barroso, Andreu Farran-Codina, Ricard Bou, Genevieve Nicolas, Inge Huybrechts, Cristina Lasheras, Esther Molina Montes, Sandra Colorado-Yohar, Alba Gasque and 17 more

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In one paragraph

Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Lucía Rizzolo-BrimeUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain.
Leila Lujan-BarrosoUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain.
Andreu Farran-CodinaDepartment of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy, Institute of Nutrition and Food Safety (INSA-UB), University of Barcelona, Santa Coloma de Gramenet, Campus de L'Alimentació de Torribera, Av. Prat de La Riba 171, Barcelona, 08921, Spain.
Ricard BouFood Safety and Functionality Program, Institute of Agrifood Research and Technology (IRTA), Finca Camps I Armet S/N, Girona, 17121- Monells, Spain.
Genevieve NicolasNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, 69008, France.
Inge HuybrechtsNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, 69008, France.
Cristina LasherasDepartment of Functional Biology, Oviedo University, Oviedo, 330066, Asturias, Spain.
Esther Molina MontesDepartment of Nutrition and Food Science, University of Granada, Granada, 18071, Spain.
Sandra Colorado-YoharCIBER of Epidemiology and Public Health (CIBERESP), Madrid, 28029, Spain.
Alba GasqueInstituto de Salud Pública y Laboral de Navarra, Pamplona, 31003, Spain.
Christina C DahmDepartment of Public Health, Aarhus University, Aarhus, 8000, Denmark.
Niels BockDepartment of Public Health, Aarhus University, Aarhus, 8000, Denmark.
Anja OlsenDepartment of Public Health, Aarhus University, Aarhus, 8000, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, DK-2100, Denmark.
Verena KatzkeDivision of Cancer Epidemiology, Germany Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Charlotte le CornetDivision of Cancer Epidemiology, Germany Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, 14558, Germany.
Calogero SaievaIstituto Per Lo Studio La Prevenzione E La Rete Oncologica (ISPRO), Florence, 5013, Italy.
Sabina SieriEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, 20133, Italy.
Maria Santucci De MagistrisA.O.U. Federico II, Naples, 80131, Italy.
Rosario TuminoHyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, 97100, Italy.
Alessandra MacciottaDepartment of Clinical and Biological Sciences, University of Turin, Turin, Orbassano (TO), 10124, Italy.
Nick WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Elisabete WeiderpassNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, 69008, France.
Chrysovalantou ChatziioannouNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, 69008, France.
Paolo VineisDepartment of Epidemiology and Biostatistics, Imperial College, London, SW7 2AZ, UK.
Paula JakszynUnit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain. paujak.ico@gmail.com.ORCID http://orcid.org/0000-0003-0672-8847

Funding

Instituto de Salud Carlos III FI20/00006Instituto de Salud Carlos III PI19/00817World Health Organization 001
6 · The paper itself

Abstract

backgroundProcessed meat (PM) consumption is an established risk factor for colorectal cancer (CRC). It has been hypothesized that nitrosyl-heme, formed by the addition of nitrites during meat processing, may enhance the carcinogenic effects of PMs. This study aims to investigate the association between nitrosyl-heme intake and CRC risk within the European Prospective Investigation into Cancer and Nutrition(EPIC) study.

methodsThis prospective study included 367,463 participants(70.3% women) from seven countries from the EPIC-study. Dietary data were collected via baseline questionnaires, and nitrosyl-heme exposure was estimated using biochemical data from 52 Spanish PMs, extrapolated to country-specific items. Sex-specific multivariable-adjusted hazard ratios(HRs) and 95% confidence intervals(CIs) were calculated using Cox proportional hazards models.

resultsOver a 15-year median follow-up, 5,115 incident CRC cases were identified. Comparing the highest vs. the lowest sex-specific tertile of nitrosyl-heme intake we found no significant association with CRC risk (HR

conclusionsThis study offers insights into nitrosyl-heme exposure in European populations but found no link to CRC risk. Further research is needed to understand nitrosyl-heme's role in CRC.

Indexed as

Colorectal NeoplasmsDietHemeMeat ProductsNitroso CompoundsAdultAgedEuropeFemaleHumansMaleMiddle AgedNitritesProportional Hazards ModelsProspective StudiesRisk FactorsHemeNitritesNitroso CompoundsColorectal cancerNitrosyl-hemeProcessed meat

Identifiers

PMID41422247
PMCPMC12831344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.