ArticleJournal of translational medicine2025
Diffuse reflectance spectroscopy for enhanced diagnostic precision in breast cancer.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Critical evaluation of "Diffuse reflectance spectroscopy for enhanced diagnostic precision in breast cancer".Journal of translational medicine · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeVacuum-assisted breast biopsy (VABB), widely used for diagnosing breast cancer, is prone to sampling errors that may necessitate repeat procedures and delay treatment. Optically guided VABB using Diffuse Reflectance Spectroscopy (DRS) may help address this limitation.
methodsTo this end, an optical introducer (a cut-out 9-gauge hollow tube) was developed and equipped with optical fibers. The tube slides over a standard VABB needle, enabling tis- sue measurements near the biopsy aperture. Ex vivo DRS measurements were performed on lumpectomy specimens from 90 patients using this tube, yielding over 500 measurement loca- tions. Tissue labels were derived through deformable image registration of measurement sites with annotated histology, and label extraction was optimized for larger fiber distances. Machine learning classifiers were trained on the spectral data.
resultsEnsemble models achieved up to 94% sensitivity at a 20% tumor threshold and maintained high performance at lower thresholds.
conclusionThese findings demonstrate that DRS enables real-time tissue characterization at large fiber distances and may improve biopsy precision. In vivo studies are needed to validate performance and support the integration of DRS into routine VABB diagnostic workflows.
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Registered trials
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