Evidence map›Paper›PMID 41422224›Full record

ArticleJournal of nanobiotechnology2025

Bioinspired smart catalytic microneedle patch with structural color for infected wound management.

Yuting Huang, Yuqi Wu, Peipei Xi, Nengjie Yang, Yongxin Xu, Hao Zhang, Yunan Wang, Xiaodong Chen, Yujuan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuting Huang *Research Center of Clinical Medicine, Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Yuqi Wu *Research Center of Clinical Medicine, Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Peipei XiDepartment of Emergency, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
Nengjie YangDepartment of Rheumatology, Research Center of Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Yongxin XuDepartment of Rheumatology, Research Center of Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Hao ZhangResearch Center of Clinical Medicine, Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Yunan WangDepartment of Rheumatology, Research Center of Immunology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China.
Xiaodong ChenResearch Center of Clinical Medicine, Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China. dermatochen@ntu.edu.cn.
Yujuan ZhuResearch Center of Clinical Medicine, Department of Dermatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, China. yujuanzhu@ntu.edu.cn.

Funding

Jiangsu Provincial Medical Key Discipline Cultivation Unit JSDW202205Jiangsu Provincial Research Hospital YJXYY202204-ZD07Jiangsu Shuangchuang Talent Program JSSCRC2024596National Natural Science Foundation of China 82102233Postgraduate Research & Practice Innovation Program of Jiangsu Province SICX24_2044Science and Technology Project of Nantong City JC2023037
6 · The paper itself

Abstract

Infected wounds remain a major clinical challenge due to persistent inflammation, excessive reactive oxygen species (ROS), and bacterial colonization. Here, we present a bioinspired catalytic microneedle (MN) patch that integrates antibacterial, anti-inflammatory, and real-time monitoring functions into a single platform. The patch possesses a hierarchical structure with spatially distributed nanocomponents: gold-modified barium titanate (AuB) in the MN tips enables ultrasound-triggered piezoelectric antibacterial activity, while cerium dioxide nanozyme (CeNP) in the backing layer efficiently scavenges ROS and mitigates inflammation. Of note, a structural color hydrogel incorporated in the backing layer provides visual, colorimetric indication of wound exudate, allowing timely patch replacement. Based on these features, it is demonstrated that the hierarchically structured MN patch exhibits robust antibacterial efficacy as well as anti-inflammatory treatment. In vivo evaluations further demonstrate its enhanced healing outcomes, which are characterized by improved tissue regeneration and accelerated resolution of inflammation. Collectively, these results highlight the potential of this smart hierarchical MN platform as an intelligent and multifunctional therapeutic strategy for efficient management of infected wounds.

Indexed as

Anti-Bacterial AgentsNeedlesWound HealingWound InfectionAnimalsAnti-Inflammatory AgentsCatalysisCeriumColorGoldHydrogelsInflammationMaleMiceReactive Oxygen SpeciesStaphylococcus aureusAnti-Bacterial AgentsAnti-Inflammatory Agentsceric oxideCeriumGoldHydrogelsReactive Oxygen SpeciesTitaniumGold-modified barium titanateInfected wound managementMicroneedle patchNanozymeStructural color

Identifiers

PMID41422224
PMCPMC12809995

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.