SynthesisBMC oral health2025
Effects of photobiomodulation therapy on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOrthodontically induced inflammatory root resorption (OIIRR) is a common complication of orthodontic treatment that may compromise tooth health and treatment outcomes. Photobiomodulation (PBM) therapy has emerged as a potential modality to mitigate against OIIRR. However, clinical studies have shown inconsistent efficacy and there is a lack of consensus on functional parameters, underscoring the need for evidence-based reviews.
methodsRandomized controlled trials (RCTs) investigating PBM for OIIRR mitigation with quantitative root resorption assessment were included in the review. An electronic search was conducted across six databases (PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, and Scopus) and the OPENGREY.EU for grey literature. References of included articles and relevant reviews were manually screened. The search was last updated on May 27th, 2025, with no publication date restrictions. The quality of included studies and evidence certainty of outcomes were assessed using the Cochrane Risk of Bias Tool 2.0 (RoB 2) and the 'Grading of Recommendations, Assessment, Development and Evaluations' (GRADE) framework. Following the heterogeneity evaluation, meta-analysis was performed on eligible studies using RevMan 5.3 software. Inter-rater agreement during study selection and quality assessment was quantified using Cohen's kappa statistics. The significance threshold was set at p < 0.05.
resultsFrom a total of 893 records, 13 RCTs were included in the systematic review, with 4 selected for meta-analysis. Among all the included studies, only two demonstrated low risk of bias. Possible functional settings of PBM for OIIRR varied across studies (output power 100-200 mW, energy density 5-10 J/cm², and per-session dose 10-100 J/tooth). Within these ranges, appropriate cumulative doses and a tapered irradiation frequency protocol could influence PBM efficacy. The meta-analysis revealed that PBM was associated with a statistically significant (p < 0.01) but modest reduction (MD: -0.13 mm³, 95% CI: -0.17 to -0.09 mm
conclusionsPBM shows potential in reducing OIIRR in the maxillary first premolar during buccal tipping, especially in the early stages of treatment. However, variability in PBM parameters and limited studies with low risk of bias indicate the need for standardized protocols and higher-quality research.
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