Evidence map›Paper›PMID 41422065›Full record

ArticleRadiation oncology (London, England)2025

Low-dose radiotherapy for benign conditions: management of persistent inguinal lymphorrea.

Verónica Cañón, Javier Anchuelo, Claudia Laborda, Ana Galán, Ana Laura Rivero, Frandeína Pinto, Mara García, Paola Navarrete, Piedad Galdós, Ana Aliaga and 7 more

Abstract read
In one paragraph

Article in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Verónica CañónHospital Universitario de Cruces, Barakaldo, Spain.
Javier AnchueloHospital Universitario Miguel Servet, Zaragoza, Spain. jtanchuelo@salud.aragon.es.
Claudia LabordaHospital Universitario Miguel Servet, Zaragoza, Spain.
Ana GalánHospital Universitario Miguel Servet, Zaragoza, Spain.
Ana Laura RiveroHospital Universitario Marqués de Valdecilla, Santander, Spain.
Frandeína PintoHospital Universitario Marqués de Valdecilla, Santander, Spain.
Mara GarcíaHospital Universitario Marqués de Valdecilla, Santander, Spain.
Paola NavarreteHospital Universitario Marqués de Valdecilla, Santander, Spain.
Piedad GaldósHospital Universitario Marqués de Valdecilla, Santander, Spain.
Ana AliagaHospital Universitario Miguel Servet, Zaragoza, Spain.
Arantxa Ayete AndreuHospital Universitario Miguel Servet, Zaragoza, Spain.
Cristina GarcíaHospital Universitario Miguel Servet, Zaragoza, Spain.
Gemma LiriaHospital Universitario San Jorge, Huesca, Spain.
Maria CerrolazaHospital Universitario Miguel Servet, Zaragoza, Spain.
Rosa FabregatHospital Universitario Marqués de Valdecilla, Santander, Spain.
Claudia Colom PlaHospital Universitario Miguel Servet, Zaragoza, Spain.
Pedro José PradaHospital Universitario Marqués de Valdecilla, Santander, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymphorrhea is a complication that can arise after vascular, abdominal or pelvic interventions and is associated with significant morbidity. While conservative management is typically effective, some cases remain refractory.

methodsThis retrospective cross-sectional study analyzed 43 patients with persistent inguinal lymphorrhea treated at a tertiary hospital between 2008 and 2018. All patients received external beam radiotherapy (EBRT) using 3D conformal techniques with photons (6-18 MV). The delivered dose was 7.5 Gy in five 1,5 Gy/fractions.

resultsComplete closure of the lymphatic fistula was achieved in all patients. Three required reirradiation with the same schedule to reach complete resolution. No acute or late toxicity was observed in any case.

conclusionsLow-dose EBRT is a safe and effective treatment option for persistent lymphorrhea refractory to conservative measures. Its anti-inflammatory and fibrosing effects support its therapeutic use in benign lymphatic complications.

trial registrationNot applicable.

Indexed as

Inguinal CanalLymphatic DiseasesRadiotherapy, ConformalAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrognosisRadiotherapy DosageRetrospective StudiesBenign pathologyExternal beam radiation therapyLow-dose radiotherapyLymphatic fistulaLymphorrhea

Identifiers

PMID41422065
PMCPMC12831360

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.