ReviewJournal of neuroinflammation2025
Aberrant brain functional network in COPD patients with cognitive impairment: clinical manifestations, mechanisms and therapeutic strategies.
Review in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Neuropsychiatric disorders in pulmonary fibrosis: from brain network alterations to inflammatory mechanisms and therapeutic implications.Journal of neuroinflammation · 2026Review
- Sedation as an Immunomodulator of Inflammatory Responses in the Lung-Brain Axis of ARDS.International journal of molecular sciences · 2026Review
- Left precuneus ALFF is associated with arterial oxygenation and cognitive impairment in patients with COPD: a resting-state fMRI study.Frontiers in neurology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cognitive impairment is a prevalent extrapulmonary manifestation of COPD. However, existing reviews have not yet systematically linked COPD-related dysregulation of brain functional networks with clinical indicators. This review bridges this gap by elucidating the pathway from pulmonary pathology to cognitive deficits via central network dysfunction, synthesizing evidence across four dimensions: clinical manifestations; physiological and pathological mechanisms; fMRI-based brain network disorders; and promising treatments. Chronic hypoxia-induced neuroinflammation, oxidative stress, and systemic inflammation propagated via the lung-brain axis were the main pathogenesis of COPD-CI. Cognitive deficits in COPD patients primarily manifest as executive function and visuospatial impairment, with some reality distinctive neural network features showing aberrant functional connectivity between the default mode network and visual network. Long-term oxygen therapy, anti-inflammatory regimens, and cognitive rehabilitation demonstrate benefits in improving cognition. Large sample, cross-sectional study is needed in the future studies, and multimodal neuroimaging should be used to delineate spatiotemporal network dynamics in COPD-CI.
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Registered trials
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