Evidence map›Paper›PMID 41422029›Full record

ArticleJournal of nanobiotechnology2025

Dual-function TA@CaCO

Qin Zhang, Ziliang Dong, Yanglin Wu, Ruoran Zhou, Quguang Li, Jesscia M Rosenholm, Cheng Huang, Liangzhu Feng, Jun Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qin Zhang *Department of Orthopedics, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, Jiangsu, P. R. China.
Ziliang Dong *Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, Jiangsu, P. R. China.
Yanglin Wu *Department of Orthopedics, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, Jiangsu, P. R. China.
Ruoran ZhouMedical College, Soochow University, Suzhou, 215001, Jiangsu, P. R. China.
Quguang LiInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, Jiangsu, P. R. China.
Jesscia M RosenholmPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, 20520, Finland.
Cheng HuangDepartment of Orthopeadics, China-Japan Friendship Hospital, Beijing, 100029, China. hcheng90@outlook.com.
Liangzhu FengInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, Jiangsu, P. R. China. lzfeng@suda.edu.cn.
Jun LinDepartment of Orthopedics, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215000, Jiangsu, P. R. China. linjun@suda.edu.cn.

Funding

Elite Medical Professionals Project of China-Japan Friendship Hospital NO.ZRJY2024-GG05National Natural Science Foundation of China 32322046National Natural Science Foundation of China 82172387National Natural Science Foundation of China 82372500National Research Programs from the Ministry of Science and Technology (MOST) of China 2022YFF0706500Natural Science Foundation of Jiangsu Province BK20230002Suzhou Medical College-QiLu Medical Research Program of Soochow University 24QL200218Suzhou Science and Technology Development Plan SKY2023035
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a globally prevalent autoimmune musculoskeletal disease that requires early-stage treatment. Initially, patients with RA exhibit elevated reactive oxygen species (ROS) levels and acidic conditions within the articular spaces. These two factors synergistically promote lipid peroxidation in M2 macrophages and lead to increased inflammation. Our work was then designed to engineer a multifunctional nanomedicine that targets the increased lipid peroxidation sensitivity of M2 macrophages. We successfully synthesized a calcium carbonate (CaCO

Indexed as

Arthritis, RheumatoidCalcium CarbonateLipid PeroxidationMacrophagesNanomedicineTanninsAnimalsHumansMaleMiceRAW 264.7 CellsReactive Oxygen SpeciesCalcium CarbonateReactive Oxygen SpeciesTanninsAcidificationCaCO3 nanoparticlesLipid peroxidationM2 macrophagesRheumatoid arthritis

Identifiers

PMID41422029
PMCPMC12838416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.