ArticleBMC infectious diseases2025
Is there any association between latent Toxoplasma gondii seropositivity and hypothyroidism? A case-control registry-based study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypothyroidism is a relatively common endocrine disorder in human societies. Toxoplasmosis is also one of the most prevalent parasitic infectious diseases in mammalian hosts, causing opportunistic infections in healthy individuals and complications in immunocompromised patients. This infection is associated with several autoimmune diseases, including autoimmune thyroid disease. This case-control study aims to investigate latent T. gondii infection in patients with hypothyroidism who were registered with the Iranian National Registry Center for Toxoplasmosis (INRCT).
methodsWe conducted a case-control study involving 118 patients diagnosed with hypothyroidism and 100 subjects without hypothyroidism, serving as the control group. The Toxoplasma status was confirmed through the enzyme-linked immunosorbent assay (ELISA) for anti-Toxoplasma IgG and IgM antibodies. Levels of T3, T4, and thyroid-stimulating hormone (TSH) were measured using chemiluminescence immunoassay (CLIA).
resultsAnti-Toxoplasma IgG was detected in 69.5% of patients with hypothyroidism (82/118) and in 35.0% of the control group (35/100) (P < 0.05). However, all participants were negative for anti-Toxoplasma IgM. Based on the results from the multiple logistic regression (LR) model, and after adjusting for confounding factors, we found that the likelihood of hypothyroidism in subjects with Toxoplasma infection is 2.4 times greater than that of seronegative individuals.
conclusionsOur results demonstrate a significant association between latent T. gondii infection (IgG seropositivity) and hypothyroidism, supporting a potential role for chronic toxoplasmosis in thyroid dysfunction. These findings contribute to the understanding of potential links between chronic infections and endocrine dysfunction. However, the clinical utility of routine T. gondii screening in hypothyroid patients remains uncertain and warrants further investigation. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.