Evidence map›Paper›PMID 41421797›Full record

ReviewAnnals of medicine2025

Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy.

Jiaao Sun, Jiahua Liu, Feng Chen, Xiaoxi Wang, Guangzhen Wu

Abstract readReview
In one paragraph

Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiaao SunDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0009-0001-2379-5067
Jiahua LiuDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Feng ChenDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0000-0002-1800-7775
Xiaoxi WangDepartment of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Guangzhen WuDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.ORCID 0000-0002-2300-8465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the important markers that distinguish tumor cells from normal cells is metabolic reprogramming. Among them, the reprogramming of fatty acid metabolism not only supports the fuel supply for energy but also meets the needs of rapid biosynthesis, providing selective growth advantages for tumor cells to resist harsh microenvironments. Due to the crucial role of fatty acid metabolic reprogramming in tumor metabolism, its various functions in cancer have attracted more and more attention. In this review, we summarize the mechanisms of fatty acid metabolic reprogramming in tumor cells and the series of responses (such as active ferroptosis signaling), analyze the potential impacts brought by fatty acid metabolic reprogramming in various human cancers and focus on the significance of targeting fatty acid metabolic pathways and dietary control in cancer treatment.

Indexed as

Fatty AcidsNeoplasmsAnimalsAntineoplastic AgentsCellular ReprogrammingFerroptosisHumansMetabolic ReprogrammingSignal TransductionTumor MicroenvironmentAntineoplastic AgentsFatty Acidsanticancer therapycancerFatty acid metabolismferroptosismetabolic reprogramming

Identifiers

PMID41421797
PMCPMC11703377

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.