Evidence map›Paper›PMID 41421661›Full record

ReviewJournal of advanced research2026

Assembly delivery of bioactive matters: Advances, challenges, and prospects.

Yi Hu, Linfang Zhong, Pengqi Wang, Jiamian Zhan, Wenhui Yang, Xiaozhong Qiu, Honghao Hou

Abstract readReview
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi HuThe Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, PR China.
Linfang ZhongThe Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong 510900, PR China.
Pengqi WangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Jiamian ZhanGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Wenhui YangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Xiaozhong QiuGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Honghao HouGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China. Electronic address: sshhh89@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssembled delivery systems (ADS) are a novel drug delivery technology that has emerged in biomedical engineering in recent years. By integrating molecular self-assembly with intelligent functional materials, ADS enables efficient delivery of drugs, genes, and bioactive substances. Compared to conventional delivery systems, ADS offer advantages such as tunable structure, controllable function, and precise responsiveness, demonstrating great potential in targeted therapy, tissue regeneration, and disease diagnosis. However, systematic conceptualization and in-depth research on ADS remain limited. AIM OF REVIEW: This review aims to clarify the fundamental principles, functional characteristics, and multidisciplinary applications of ADS. It elucidates their material design, self-assembly mechanisms, and delivery strategies, emphasizes core advantages of ADS, and outlines current challenges and future directions. It provides theoretical support and technical pathways for developing intelligent, efficient, and personalized ADS, accelerating their translation from laboratory research to clinical application. KEY SCIENTIFIC CONCEPTS OF REVIEW: The core principle of ADS lies in the synergistic integration of molecular self-assembly and stimulus-responsive smart materials, enabling the rational design of carriers with precise structure-function relationships for the intelligent delivery of bioactive agents. Key advantages of ADS include precise targeting through multi-level strategies, intelligent responsiveness, multimodal synergy, enhanced biocompatibility, and flexible engineering. Representative breakthroughs have been achieved in drug delivery, tissue engineering, and gene editing. Furthermore, the convergence of ADS with emerging technologies, such as artificial intelligence and microfluidics, offers a strategic pathway toward next-generation systems that are efficient, intelligent, and highly precise, establishing new paradigms for biomedical applications.

Indexed as

Drug Delivery SystemsAnimalsBiocompatible MaterialsDrug CarriersHumansTissue EngineeringBiocompatible MaterialsDrug CarriersAssembled delivery systemsBiomedical engineeringDrug deliveryGene editingTissue engineering

Identifiers

PMID41421661
PMCPMC13539259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.