Evidence map›Paper›PMID 41421660›Full record

ArticleJournal of advanced research2026

Motion-driven piezoelectric response in self-powered hydrogel nanofibers enhances wound healing via intermediate filament remodeling and modulation of energy metabolism.

Ruijie Xu, Jiajia Yu, Jiale Diao, Bo Xue, Min He, Yuanyue Li, Xiaoting Peng, Zhao Yao, Bingcheng Yi, Qihui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruijie XuNHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China; College of Electronics and Information, Qingdao University, Qingdao 266071, China. Electronic address: xuruijie@qdu.edu.cn.
Jiajia YuDepartment of Traditional Chinese Medicine, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao 266042, China. Electronic address: Yjj202306@126.com.
Jiale DiaoSchool of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China. Electronic address: 13296387729@163.com.
Bo XueNHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China. Electronic address: gj0748752@gmail.com.
Min HeQingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao 266033, China. Electronic address: hmjycwdy@163.com.
Yuanyue LiCollege of Electronics and Information, Qingdao University, Qingdao 266071, China. Electronic address: yyli@qdu.edu.cn.
Xiaoting PengNHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China. Electronic address: pengxiaoting@uhrs.edu.cn.
Zhao YaoCollege of Electronics and Information, Qingdao University, Qingdao 266071, China. Electronic address: yzh17@qdu.edu.cn.
Bingcheng YiNHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China; Department of Traditional Chinese Medicine, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao 266042, China. Electronic address: yibingcheng@uhrs.edu.cn.
Qihui ZhouNHC Key Laboratory of Cardiopulmonary Rehabilitation and Functional Recovery (University of Health and Rehabilitation Sciences), Shandong Key Laboratory of Neurorehabilitation, Shandong Engineering Research Center for Tissue Rehabilitation Materials and Devices, Qingdao Key Laboratory of Smart Rehabilitation Material, School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266113, China. Electronic address: qihuizhou@uhrs.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic regulation is essential for tissue homeostasis and for competence to activate the repair process in damaged tissue. Considering that bioelectric signals possess the ability to regulate cellular membrane potential and cellular energy metabolism for cell activation and skin physiological homeostasis, this study introduces a biomimetic, self-powered piezoelectric hydrogel nanofiber platform to reconstruct the bioelectrical microenvironment and offers a collagen fiber-like structure and antioxidant/anti-inflammatory properties to support intermediate filament remodeling and energy metabolism intervention for therapeutic advances in severe wound repair. Results demonstrate the successful fabrication of the collagen fiber-like substrate through the combination of electrospinning and photo-crosslinking of gelatin methacryloyl. Afterwards, the incorporation of tetragonal barium titanate nanoparticles significantly endows the substrate with notable piezoelectric properties, while tannic acid (TA) modification effectively mitigates the severe inflammatory microenvironment. When implanted in a rat model of dorsal skin injury, the piezoelectric hydrogel nanofibers are noted to markedly promote epidermal regeneration and accelerate skin wound healing. Transcriptome analysis reveals the mechanisms by which the TA-modified biomimetic hydrogel nanofibers enhance cell recruitment through cytokine-cytokine receptor interaction pathways and accelerate skin repair via immune response regulation. Furthermore, piezoelectric stimulation facilitates skin regeneration by activating linoleic acid-related metabolisms, preventing skin aging through the estrogen signaling pathway, and suppressing skin fibrosis by regulating the remodeling of motor protein-mediated contractile cytoskeleton. Overall, this work is poised to advance the development of bioelectricity-induced wound dressings, opening a new avenue for the management of severe skin wounds.

Indexed as

Energy MetabolismHydrogelsNanofibersWound HealingAnimalsCollagenGelatinMaleRatsRats, Sprague-DawleySkinTanninsCollagenGelatinHydrogelsTanninsAnti-inflammationBioelectric stimulationHydrogel nanofibersPiezoelectric effectWound healing

Identifiers

PMID41421660
PMCPMC13539323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.