Evidence map›Paper›PMID 41421422›Full record

ArticleOsteoarthritis and cartilage2026

Comprehensive zonal assessment of meniscal degeneration using quantitative UTE MRI.

Arya Suprana, Mahyar Daskareh, Hee Dong Chae, Jiaji Wang, Jiyo Athertya, Soo Hyun Shin, Eric Y Chang, Robert L Sah, Graeme M Bydder, Jiang Du and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arya SupranaDepartment of Radiology, University of California San Diego, CA, USA; Department of Bioengineering, University of California San Diego, CA, USA. Electronic address: asuprana@ucsd.edu.
Mahyar DaskarehDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: mdaskareh@health.ucsd.edu.
Hee Dong ChaeDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: hdchae02@gmail.com.
Jiaji WangDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: jiw245@health.ucsd.edu.
Jiyo AthertyaDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: jathertya@health.ucsd.edu.
Soo Hyun ShinDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: shs033@health.ucsd.edu.
Eric Y ChangDepartment of Radiology, University of California San Diego, CA, USA; Radiology Service, VA San Diego Healthcare System, CA, USA. Electronic address: e8chang@health.ucsd.edu.
Robert L SahDepartment of Bioengineering, University of California San Diego, CA, USA. Electronic address: rsah@ucsd.edu.
Graeme M BydderDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: gbydder@health.ucsd.edu.
Jiang DuDepartment of Radiology, University of California San Diego, CA, USA; Department of Bioengineering, University of California San Diego, CA, USA; Radiology Service, VA San Diego Healthcare System, CA, USA. Electronic address: jiangdu@ucsd.edu.
Yajun MaDepartment of Radiology, University of California San Diego, CA, USA. Electronic address: yam013@health.ucsd.edu.

Funding

Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of BoneR01AR068987 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2024
$4.9M
Quantitative UTE MR Imaging: Sensitive Biomarkers for OsteoarthritisR01AR062581 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2013 to 2022
$4.1M
Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging of EnthesesR01AR075825 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2019 to 2023
$1.8M
Ultrashort Echo Time Magnetic Resonance Imaging of the Knee JointR01AR085008 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jiang Du · 2025 to 2026
$1.3M
Comparison of direct and indirect magnetic resonance imaging of myelin in Alzheimer's diseaseF32AG082458 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ATHERTYA, JIYO S · 2023 to 2025
$256k
BLRD VA I01 BX005952NIAMS NIH HHS R01 AR062581NIAMS NIH HHS R01 AR068987NIAMS NIH HHS R01 AR075825NIAMS NIH HHS R01 AR079484NIAMS NIH HHS R01 AR085008NIA NIH HHS F32 AG082458
6 · The paper itself

Abstract

objectiveKnee menisci consist of three zones-red-red (RR), red-white (RW), and white-white (WW) zones, which may be differentially affected by osteoarthritis (OA). Zone-specific quantitative imaging techniques are valuable in understanding OA progression. The study utilized a comprehensive set of ultrashort-echo-time (UTE) MRI sequences, including UTE-T

methodsSixty-two volunteers (mean-age 55±17 years; 30 females; 46 patients with radiographic OA) participated in the study. UTE techniques were employed to quantify T

resultsA total of 178 meniscal regions were analyzed, with 65 classified as grade-1 (normal), 80 as grade-2 (mild-degeneration), and 33 as grade-3 (advanced-degeneration). Significant differences in all UTE measurements were clearly observed between the three zones in normal menisci. These differences became less distinct with increasing degeneration. Furthermore, within each zone, T

conclusionThe study highlights the potential of UTE measurements to differentiate normal meniscal zonal composition and detect early changes due to degeneration, offering a promising tool for comprehensive knee-OA assessment and treatment monitoring.

Indexed as

Magnetic Resonance ImagingMenisci, TibialOsteoarthritis, KneeAdultAgedDisease ProgressionFemaleHumansMaleMiddle AgedMeniscusOsteoarthritisUTE measurementsUTE MRIVascular zones

Identifiers

PMID41421422
PMCPMC12888804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.