ArticleCell reports. Medicine2026
Blood metabolic panels for identifying significant fibrosis and inflammation in patients with MASLD.
Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Survivin mRNA lipid nanoparticles and CTLA-4 inhibitor co-delivery activates anti-tumor cytotoxic T-lymphocytes for oral cancer immunotherapy.Medical oncology (Northwood, London, England) · 2026Article
- Review
- Metabolic reprogramming in fibrosis-related diseases: underlying mechanisms and therapeutics.Molecular biomedicine · 2026Review
- A novel serum metabolite classifier for identifying Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) integrating metabolomics and machine learning.BMC gastroenterology · 2026Article
- Sex differences in behaviors, neuronal activation, and gut-microbiota-metabolic axis in a repeated nitroglycerin-induced chronic migraine model.The journal of headache and pain · 2026Article
- Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) remains a prevalent condition with limited diagnostic and therapeutic options. This study aims to identify metabolic signatures of disease progression and develop non-invasive diagnostic models through three independent cohorts (including two cohorts confirmed by biopsy and one cohort confirmed by ultrasound) involving 293 participants for detecting significant fibrosis (≥F2) and mild to severe inflammatory activity (≥I2) using multiple machine learning techniques. The fibrosis panel shows area under the receiver operating characteristic curve (AUROC) of 0.928 (95% confidence interval [CI]: 0.835-0.978), 0.829 (0.732-0.902), and 0.806 (0.724-0.872) in the discovery cohort, validation cohort 1, and validation cohort 2, respectively, outperforming the fibrosis-4 index (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), non-alcoholic fatty liver disease fibrosis score (NFS), liver stiffness measurement (LSM), and combination of hoMa, Ast and CK18 (MACK-3). The inflammation panel achieves AUROCs of 0.894 (0.791-0.957) and 0.776 (0.673-0.859) in the discovery cohort and validation cohort 1, respectively. The key metabolites guanidinoacetic acid (GAA) and sebacic acid (SA) demonstrate therapeutic efficacy in mice. These validated panels provide accurate stratification of MASLD severity, and GAA/SA offer therapeutic potential, advancing both diagnosis and treatment strategies.
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