Evidence map›Paper›PMID 41421351›Full record

ArticleCell reports. Medicine2026

Microbial-derived immunostimulatory small molecule augments anti-PD-1 therapy in lung cancer.

Rachel C Newsome, Huijia Liu, Bright Agbodzi, Raad Z Gharaibeh, Liang Zhou, Christian Jobin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel C NewsomeDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Huijia LiuDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Bright AgbodziUF Genetics Institute, University of Florida, Gainesville, FL, USA.
Raad Z GharaibehDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA.
Liang ZhouDepartment of Infectious Diseases and Immunology, University of Florida College of Medicine, Gainesville, FL, USA.
Christian JobinDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, USA; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA; Department of Infectious Diseases and Immunology, University of Florida College of Medicine, Gainesville, FL, USA. Electronic address: christian.jobin@medicine.ufl.edu.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
University of Florida Health Cancer Center Support GrantP30CA247796 · NCI · UNIVERSITY OF FLORIDA · PI JI-HYUN LEE · 2023 to 2026
$10.9M
Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9M
Team-based Interdisciplinary Cancer Research Training ProgramT32CA257923 · NCI · UNIVERSITY OF FLORIDA · PI SIEMANN, DIETMAR W · 2021 to 2025
$1.2M
Role of bacterial-derived small molecules in immunotherapyR01CA292532 · NCI · UNIVERSITY OF FLORIDA · PI Christian Jobin · 2025 to 2026
$1.1M
Acquisition of timsTOF Pro for Complex Lipidomic AnalysesS10OD030250 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2022 to 2022
$658k
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
Olympus VS200 Brightfield/Fluorescence whole slide scanner with slide towerS10OD032236 · OD · UNIVERSITY OF FLORIDA · PI CAMPBELL-THOMPSON, MARTHA · 2023 to 2023
$290k
NCATS NIH HHS TL1 TR001428NCATS NIH HHS UL1 TR001427NCI NIH HHS P30 CA247796NCI NIH HHS R01 CA292532NCI NIH HHS T32 CA257923NIH HHS S10 OD021758NIH HHS S10 OD030250NIH HHS S10 OD032236
6 · The paper itself

Abstract

We previously showed that enrichment of the Bacteroides genus is associated with improved anti-PD-1-mediated tumor therapy. Here, we isolate 183 Bacteroides isolates from the feces of humanized anti-PD-1 responder mice. Supernatants from 6 of 183 isolates stimulate IFNγ production from primary CD8

Indexed as

BacteroidesImmune Checkpoint InhibitorsLung NeoplasmsProgrammed Cell Death 1 ReceptorAnimalsCD8-Positive T-LymphocytesCell Line, TumorFecesFemaleHumansInterferon-gammaMiceMice, Inbred C57BLImmune Checkpoint InhibitorsInterferon-gammaProgrammed Cell Death 1 Receptorimmune checkpoint inhibitionimmunotherapymicrobiomenon-small cell lung cancer

Identifiers

PMID41421351
PMCPMC12866101

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.