Evidence map›Paper›PMID 41421150›Full record

ArticleNeuroImage. Clinical2026

Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder.

Nick Steele, Ahmed Hussain, Delin Sun, Courtney Russell, Ashley A Huggins, Nicholas D Davenport, Seth G Disner, Scott R Sponheim, Thomas Straube, David Hofmann and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Nick SteeleBrain Imaging and Analysis Center, Duke University, Durham, NC, USA,; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA. Electronic address: Njs58@duke.edu.
Ahmed HussainBrain Imaging and Analysis Center, Duke University, Durham, NC, USA,; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Delin SunBrain Imaging and Analysis Center, Duke University, Durham, NC, USA,; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA.
Courtney RussellBrain Imaging and Analysis Center, Duke University, Durham, NC, USA,; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
Ashley A HugginsDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry , University of Minnesota, Minneapolis, MN, USA.
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry , University of Minnesota, Minneapolis, MN, USA.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, MN, USA.
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
David HofmannInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Shmuel LissekDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Hannah BergDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Daniel W GrupeCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA.
Jack B NitschkeDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
Ruth LaniusDepartment of Neuroscience, Western University, London, ON, Canada; Department of Psychiatry, Western University, London, ON, Canada.
Maria DensmoreDepartment of Psychiatry, Western University, London, ON, Canada.
Jean ThébergeDepartment of Psychiatry, Western University, London, ON, Canada.
Richard W J NeufeldDepartment of Psychiatry, Western University, London, ON, Canada.
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Rajendra A MoreyBrain Imaging and Analysis Center, Duke University, Durham, NC, USA,; Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC, USA.

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
Neural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Neurobiologically-Based Subtyping of Multi-Cohort Samples with MDD and PTSD SymptomsR01MH129832 · NIMH · DUKE UNIVERSITY · PI MOREY, RAJENDRA A, SCHMAAL, LIANNE · 2022 to 2025
$2.3M
Structural and Functional Architecture of Cortico-Cerebellar Systems in Posttraumatic Stress Disorder and TraumaR01MH139648 · NIMH · DUKE UNIVERSITY · PI RAJENDRA A MOREY, Jennifer Strafford Stevens · 2025 to 2026
$1.1M
NICHD NIH HHS P30 HD003352NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH129832NIMH NIH HHS R01 MH139648NIMH NIH HHS T32 MH018931RRD VA I01 RX000622RRD VA IK1 RX002325RRD VA IK2 RX000709RRD VA IK2 RX002922
6 · The paper itself

Abstract

The thalamus exhibits widespread connectivity to the entire cortical mantle, yet distinct thalamic subregions possess unique connectivity profiles and functional roles. While the thalamus has been consistently implicated in posttraumatic stress disorder (PTSD), fine-grained investigations examining thalamic subregions and nuclei remain sparse. We examined how resting-state functional connectivity (RSFC) of thalamic nuclei with the cortex and large-scale brain networks may contribute to PTSD using high-resolution functional magnetic resonance imaging (fMRI) data from a multi-site dataset of PTSD cases and controls (n = 397). We show that the pulvinar nuclei exhibit weaker RSFC with sensorimotor and salience regions, while the medial geniculate nucleus (MGN) exhibits stronger RSFC with the sensorimotor cortex in PTSD. Greater PTSD severity correlated with weaker RSFC between both the pulvinar and mediodorsal thalamus and cortical sensory/motor regions in the frontal, parietal, and occipital lobes. We identified that the default mode network of PTSD participants had stronger RSFC with the mediodorsal thalamus, while the salience and somatosensory networks exhibited stronger RSFC with somatomotor thalamic nuclei. Fine-grained thalamic mapping is important for uncovering thalamocortical disruptions in PTSD. Thalamic RSFC shows a shift toward heightened subcortical sensory responsivity and diminished voluntary control and cognitive regulation in PTSD.

Indexed as

Cerebral CortexNerve NetStress Disorders, Post-TraumaticThalamusAdultConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysYoung AdultLarge-scale networksMediodorsal thalamusPTSDPulvinarResting-state functional connectivityThalamic nuclei

Identifiers

PMID41421150
PMCPMC12775856

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.