Evidence map›Paper›PMID 41421055›Full record

ArticleGeneral hospital psychiatry

Clinical and biological distinctions between catatonia due to a medical condition and catatonia associated with a psychiatric disorder.

Laura Duque, Nik Ghafouri, Christopher A Fuguet, Liliana Patarroyo-Rodriguez, Vanessa K Pazdernik, Kemuel L Philbrick, John D Port, Rodolfo Savica, Teresa A Rummans, Balwinder Singh

Abstract read
In one paragraph

Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Catatonia treatments and risk of recurrence.Journal of affective disorders · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura DuqueDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA. Electronic address: laura.duque@pennmedicine.upenn.edu.
Nik GhafouriDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry and Behavioral Sciences, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.
Christopher A FuguetDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry & Psychology, Mayo Clinic Health System, Eau Claire, WI, USA.
Liliana Patarroyo-RodriguezDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Vanessa K PazdernikDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Kemuel L PhilbrickDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
John D PortDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Rodolfo SavicaDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Teresa A RummansDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Mayo Clinic, Jacksonville, FL, USA.
Balwinder SinghDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA. Electronic address: Singh.Balwinder@mayo.edu.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
NCATS NIH HHS KL2 TR002379NCATS NIH HHS UL1 TR002377
6 · The paper itself

Abstract

objectiveTo identify differences between catatonia due to a medical condition (CMC) and catatonia associated with a psychiatric disorder (CPD) based on clinical, biological, and treatment features.

methodsThis was a retrospective cohort study spanning 20 years (2001-2021). Patients diagnosed with catatonia were categorized into CMC or CPD as per DSM-5 criteria. Study outcomes included (1) severity of catatonia at diagnosis, defined using the Bush-Francis Catatonia Rating Scale (BFCRS) and Clinical Global Impression-Severity (CGI-S), (2) catatonia response to lorazepam, (3) time to discharge as a proxy for overall improvement, and (4) identification of clinical features that differentiate between CMC and CPD. To examine the relationship between clinical characteristics and CMC versus CPD, we used Least Absolute Shrinkage and Selection Operator (LASSO) for variable selection, followed by a final model to estimate associations.

resultsOf 249 patients diagnosed with catatonia, 191 had CPD and 58 had CMC (mean age [SD] 48.3 [20.3] years, female n = 138 [55.4 %]). Patients with CMC exhibited higher severity at diagnosis (CGI-S p < 0.001, BFCRS p = 0.005) and more complications (81.0 % vs. 49.7 %, p < 0.001), including delirium (32.8 % vs. 5.2 %, p < 0.001) and were less likely to respond to lorazepam (34 % vs. 55.6 %, p = 0.007). Adjusting for age and sex, Cox proportional hazards model indicated a reduced hazard for discharge in patients with CMC, suggesting a shorter time to discharge for patients with CPD (HR = 0.71, 95 % CI 0.52-0.96, p = 0.02). Predictors for CMC included negativism, delirium, history of seizures, focal abnormalities on head CT, antipsychotic use history, and electroencephalographic abnormalities, achieving an area under the curve (AUC) of 0.87.

conclusionsOur study suggests potential differences between individuals with CMC and CPD, pointing to the possibility of more precise, individualized care.

Indexed as

CatatoniaLorazepamMental DisordersAdultFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexLorazepam

Identifiers

PMID41421055
PMCPMC12988653

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.