ArticleSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2026
Identification of water compartment in bone using ATR-FTIR spectroscopy.
Article in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Raloxifene injections normalize age-related mechanical sensitization in female and male mice and augment intervertebral disc structure in old female mice.Osteoarthritis and cartilage · 2026Article
- Injury Induces More Severe Biomechanical Changes in Middle-Aged and Geriatric Lumbar Spines in a Mouse Ex Vivo Model.JOR spine · 2025Article
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3 authors.
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Abstract
Water bound to the matrix in bone contributes significantly to its mechanical integrity, particularly to the ductility of the organic matrix. Attenuated Total Reflectance Fourier-transform infrared (ATR-FTIR) spectroscopy has been widely used to evaluate bone compositional quality and is sensitive to the detection of water. However, no study has used this technique to quantify bone hydration. Therefore, we sought to use ATR-FTIR spectroscopy to identify and validate the water compartment in bone (including both free and bound water). We conducted a series of dehydration, hydrogen/deuterium (H/D) exchange, and glycation experiments on human bone tissue and investigated changes in signal intensity in the OH region of ATR-FTIR spectra. We identified four sub-peaks (∼3200 cm
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