Evidence map›Paper›PMID 41420864›Full record

ArticleCell reports2026

Distinct contributions of Etv2

Dereck Alleyne, Minseo Kim, Jun Wu, Yoojung Kwon, Ye-Ram Kim, Ashraf Ul Kabir, Matthew Ishahak, Jeffrey R Millman, Changxu Fan, Hyung Joo Lee and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dereck AlleyneDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Developmental, Regenerative, and Stem Cell Biology Program, Washington University School of Medicine, St. Louis, MO, USA.
Minseo KimDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Jun WuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Yoojung KwonDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Ye-Ram KimDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Ashraf Ul KabirDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Matthew IshahakDivision of Endocrinology, Diabetes and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jeffrey R MillmanDivision of Endocrinology, Diabetes and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Changxu FanDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Hyung Joo LeeDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Karen KrchmaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Xiaoyun XingDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Kory LavineDivision of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Ting WangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Kyunghee ChoiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Developmental, Regenerative, and Stem Cell Biology Program, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: kchoi@wustl.edu.

Funding

DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
Hemangioglast Development and RegulationR01HL055337 · NHLBI · WASHINGTON UNIVERSITY · PI CHOI, KYUNGHEE · 2001 to 2024
$9.1M
NHLBI NIH HHS R01 HL055337NIDDK NIH HHS T32 DK007120
6 · The paper itself

Abstract

The ETS family transcription factor ETV2, VEGFA, and its receptor FLK1 are essential for hematopoietic, vascular, and cardiac development. Here, we combine dual Etv2 and Flk1 lineage tracing with molecular profiling to define how mesoderm progenitors are allocated to hematopoietic, endothelial, cardiomyocyte, and smooth muscle lineages. We demonstrate that hematopoietic, endothelial, and cardiac valves arise from dual Etv2

Indexed as

Cell LineageEndothelial CellsHematopoietic Stem CellsTranscription FactorsVascular Endothelial Growth Factor Receptor-2AnimalsHematopoiesisMesodermMiceMyocytes, CardiacER71 protein, mouseTranscription FactorsVascular Endothelial Growth Factor Receptor-2BAF155BRG1cardiomyocyteCP: developmental biologyCP: metabolismendotheliumETV2FLK1hematopoiesissmooth muscleVEGF

Identifiers

PMID41420864
PMCPMC13003410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.