Evidence map›Paper›PMID 41420860›Full record

ArticleCell reports2026

Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.

Mingyao Yang, Melissa J Oatley, Deqiang Miao, Lisette A Maddison, Jon M Oatley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingyao YangCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA.
Melissa J OatleyCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA.
Deqiang MiaoCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA.
Lisette A MaddisonCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA.
Jon M OatleyCenter for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA. Electronic address: joatley@wsu.edu.

Funding

Mechanisms of stem cell specification in the male germlineR01HD101223 · NICHD · WASHINGTON STATE UNIVERSITY · PI OATLEY, JON M · 2020 to 2023
$2.0M
NICHD NIH HHS R01 HD101223
6 · The paper itself

Abstract

The maturation of spermatids to fertilization-competent sperm is a sophisticated process required for sexual reproduction, and biogenesis of the cytoplasmic droplet (CD) is a key event. Here, we demonstrate that two proteins with testis-specific expression, arrestin domain-containing 5 (ARRDC5) and testis expressed 38 (TEX38), physically interact, are required for normal sperm maturation, and play a critical role in CD formation and function. In the CDs of Arrdc5

Indexed as

CytoplasmSpermatozoaAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutSperm MotilityARRDC5CP: Cell biologyCP: Developmental biologycytoplasmic dropletfertilitymitochondriaspermatozoaspermiogenesissperm maturationTEX38TOMM40TOMM70

Identifiers

PMID41420860
PMCPMC12927553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.