ReviewArchives of pharmacal research2026
Unlocking drug development: the distinctive roles of PET and SPECT imaging from molecular kinetics to therapeutic response.
Review in Archives of pharmacal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Drug development is a multifaceted and time-intensive process that spans candidate discovery, formulation, pharmacokinetics (PK), and evaluation of therapeutic efficacy and safety. Nuclear medicine imaging-particularly positron emission tomography (PET) and single-photon emission computed tomography (SPECT)-enables noninvasive, quantitative, and dynamic assessments of drug behavior at the molecular and systemic levels. These modalities visualize real-time biodistribution, tissue PK, target engagement, and treatment response, addressing the limitations of conventional approaches such as plasma sampling and invasive tissue biopsies. This review summarizes the contributions of PET and SPECT across the drug development continuum. Representative case studies illustrate their applications in characterizing molecular kinetics, informing pharmacokinetic and pharmacodynamic (PK/PD) relationships, evaluating target specificity, and detecting early off-target effects. We also discuss how imaging-derived metrics can support earlier go/no-go decisions, enhance preclinical-to-clinical translation through a shared quantitative framework across species and disease models, and inform individualized therapeutic strategies. Overall, PET and SPECT serve as core tools that improve the accuracy, safety, and efficiency of modern drug development for molecularly targeted therapies.
Indexed as
Identifiers
41420788What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.