ArticleHepatology international2026
Epidemiological trends and age-period-cohort analysis of alcoholic liver cancer from 1990 to 2021.
Article in Hepatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Reply to the Letter to the Editor on "Acute kidney injury stage 1a increases mortality of patients with cirrhosis-a prospective multicenter cohort study".Hepatology international · 2026Article
- Commentary on "USP13 promotes hepatic stellate cells activation and aggravates liver fibrosis through deubiquitinating SMAD3".Hepatology international · 2026Article
- Comment on "Small extracellular vesicles derived from lipotoxic hepatocytes transport FASN to promote hepatic stellate cell activation".Hepatology international · 2026Article
- Methodological considerations for recombinant human serum albumin clinical translation.Hepatology international · 2026Article
- Recombinant human serum albumin: a true therapeutic substitute or merely a serum level elevator?Hepatology international · 2026Article
- Global burden of gout attributable to high BMI (1990-2021) and causal link with obesity: a GBD and Mendelian randomization study.Therapeutic advances in endocrinology and metabolism · 2026Article
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7 authors.
Funding
Abstract
backgroundThe disease burden of alcoholic liver cancer (ALC) has been changing due to socioeconomic development. An up-to-date evaluation of this change can increase public awareness and facilitate health policy development.
methodsThe data were extracted from the Global Burden of Diseases Study (GBD) 2021. Epidemiological changes of morbidity and mortality in different regions, as well as the differences in gender and age were analyzed. Temporal trends were determined using Joinpoint regression analysis and age-period-cohort analysis was employed to evaluate the effects of age, period, and cohort.
resultsGlobally, there were 99,543.67 new cases (95% UI 80957.40-120401.87) and 92,227.78 deaths (95% UI 75053.11-112,160.27) in 2021, increased by 158.92% and 141.61%, respectively, compared to 1990. Decomposition analysis revealed that population growth was the primary driver of the increased morbidity (41.13%) and mortality (54.87%). The global estimated annual percentage change (EAPC) of morbidity and mortality exhibited an ascending trend, while differences existed across different regions. The morbidity and mortality rates were higher in males than in females across all age groups. Joinpoint regression analysis showed an increased morbidity and mortality rate. The age effect indicated that the highest risk was observed at 75-79 years for morbidity and 80-84 years for mortality. The period effect showed an increasing risk, while improving cohort risks for mortality were identified.
conclusionAlcoholic liver cancer has posed an increasing health burden since 1990, particularly affecting male and the elderly population. Effective prevention policies on specific age groups should be formulated to improve this situation.
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