Evidence map›Paper›PMID 41420669›Full record

ArticleNeurochemical research2025

Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer's Disease Rat Model.

Fatih Kirkbir, Taner Atasoy, Davar Khodadadai, Heidar Sajedi, Ozlem Keskin, Mohammad Babaie

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fatih KirkbirDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey.
Taner AtasoyDepartment of Exercise and Sports Sciences for Individuals with Disabilities, Faculty of Sport Sciences, Istanbul Gelisim University, Istanbul, Turkey.
Davar KhodadadaiFaculty of Physical Education and Sports Sciences, Islamic Azad University Central Tehran Branch, Tehran, Iran. davar.khodadadi@yahoo.com.
Heidar SajediFaculty of Health Science, Department of Exercise and Sports Science for Disabled People, International Science and Technology University, Warsaw, Poland.
Ozlem KeskinSport Science Faculty, Physical Education Department, Sinop University, Sinop, Turkey.
Mohammad BabaieDepartment of Physical Education and Sports Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial disorder that demands a comprehensive management strategy. Both aerobic exercise training and intermittent fasting (IF) have been shown to ameliorate AD symptoms, yet the impact of exercise in the fasted state remains understudied. This study compared the effects of four weeks of moderate‑intensity treadmill running in either a fasted or a normal fed state on cognitive function and hippocampal BDNF signaling in an amyloid-β (Aβ)

Indexed as

Alzheimer DiseaseBrain-Derived Neurotrophic FactorCognitionFastingHippocampusPhysical Conditioning, AnimalAmyloid beta-PeptidesAnimalsCyclic AMP Response Element-Binding ProteinDisease Models, AnimalMalePeptide FragmentsRatsRats, WistarSignal TransductionAmyloid beta-Peptidesamyloid beta-protein (1-42)Bdnf protein, ratBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinPeptide FragmentsAerobic exerciseAlzheimer's diseaseBDNFCognitive functionIntermittent fastingΒ-hydroxybutyrate

Identifiers

PMID41420669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.