Evidence map›Paper›PMID 41420665›Full record

ArticleInflammation2025

Alpha-1 Antitrypsin Mediates Spontaneous Resolution of Acute Gouty Inflammation Via Inhibiting Caspase 3/GSDME-dependent Macrophage Pyroptosis.

Xin Li, Lei Liu, Shuting Tong, Fangying Wang, Lingjiang Zhu, Qi Cheng, Peiyu Zhang, Mo Chen, Yifan Xie, Li Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin Li *Department of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Lei Liu *Department of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Shuting TongDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Fangying WangDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Lingjiang ZhuDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Qi ChengDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Peiyu ZhangDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Mo ChenDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Yifan XieDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Li WangDepartment of Hematology and Rheumatology, The First People's Hospital of Zhaotong, Zhaotong Hospital, Affiliated to Kunming Medical University, Zhaotong, 657000, China.
Hang YuDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Huaxiang WuDepartment of Rheumatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. wuhx8855@zju.edu.cn.

Funding

National Natural Science Foundation of China 82200995National Natural Science Foundation of China,China 82071810
6 · The paper itself

Abstract

Research on spontaneous resolution of acute gout remains limited. Macrophages pyroptosis is crucial for the inflammation of acute gout, while current research mainly focus on Caspase 1/Gasdermin D axis. We aimed to investigate the involvement of other Gasdermin proteins in MSU crystal-induced macrophages, and to explore the role of Caspase 3-interacting protein alpha-1 antitrypsin (AAT) in regulating macrophage pyroptosis. Here, clinical evidence demonstrated elevated Gasdermin E (GSDME) in peripheral blood mononuclear cells (PBMCs) and CD68

Indexed as

alpha 1-AntitrypsinArthritis, GoutyCaspase 3GoutMacrophagesPhosphate-Binding ProteinsPyroptosisAcute DiseaseAnimalsGasderminsHumansInflammationMaleMiceTHP-1 Cellsalpha 1-AntitrypsinCASP3 protein, humanCaspase 3GasderminsGSDME protein, humanPhosphate-Binding ProteinsAlpha-1 antitrypsinGoutGSDMEMacrophagePyroptosis

Identifiers

PMID41420665
PMCPMC12722401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.