SynthesisEpilepsia open2026
Clock gene dysregulation in epilepsy: A systematic review.
Synthesis in Epilepsia open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clock gene dysregulation in epilepsy: A systematic review.Epilepsia open · 2026Pooled it
- Molecular Mechanisms of Seizure Gating in Sleep-Related Epilepsy: Genes, Channels, Sleep Stages and Circadian Rhythm.Current issues in molecular biology · 2026Review
- Multi-Omics Dissection of the Shared Genetic Architecture Between Sleep Traits and Epilepsy.Biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveEpileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy. This systematic review sought to answer the research question: what is the relationship between clock genes and the pathophysiology of epilepsy?
methodsFor this, we used Scopus, Embase, Medline, CINHAL, and Web of Sciences to summarize the up-to-date literature on this topic and included 26 articles out of the 6364 articles identified.
resultsWe describe three distinct approaches to this research: (a) the effect of clock genes knockout on the severity of epilepsy, (b) the expression of clock genes in different types of epilepsy (humans and/or animal models) and (c) the variants of clock genes in different types of epilepsy (humans). Our results show a paucity of studies with very heterogeneous methodology and outcomes, with conflicting results. Most studies suggest a protective role of clock genes in epilepsy, particularly of Clock and Bmal1, showing lowered clock gene expression in different animal models of epilepsy, in line with the increased severity of epilepsy after knockout of clock genes. There are, though, other studies with conflicting results, making this interpretation relatively weak. A few clock gene variants were also identified in epilepsy cases (humans). SIGNIFICANCE: This suggests the need to further clarify the implications of the dysregulation of the clock genes and of the genes encoding interacting proteins, as this might offer new insights into the circadian patterning of certain epilepsies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.