ArticleThe Journal of clinical endocrinology and metabolism2026
Effects of Growth Hormone (GH) Deficiency and GH Replacement Therapy on Health-Related Physical Fitness in Children.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
contextThe effects of growth hormone deficiency (GHD) and GH replacement therapy (GHRT) on health-related physical fitness are still unclear.
objectiveThis work aimed to characterize the effects of GHD and GHRT on health-related physical fitness in children.
methodsWe enrolled 49 GHD children (aged 10.7 ± 1.9 years) and 46 controls (aged 11.8 ± 2.3 years). Both groups underwent baseline assessment of body composition, muscle strength, flexibility, cardiorespiratory fitness, insulin-like growth factor-1, metabolic equivalents (METs-min/wk), sitting time, and health-related quality of life (HRQoL). These parameters were reevaluated in GHD patients after 1-year GHRT.
resultsCompared to controls, GHD patients exhibited higher sitting time (3603.5 ± 1334.8 min/wk vs 3011.6 ± 1215.3 min/wk; P = .03), and waist-to-height ratio (WtHR) (0.50 ± 0.07 vs 0.45 ± 0.06; P = .001), reduced muscle strength (squat jump 13.88 ± 4.0 vs 15.7 ± 4.2 cm; P = .04; long jump 114.6 ± 25.8 vs 126.2 ± 29.6 cm; P = .04; counter-movement jump 13.7 ± 3.9 vs 16.4 ± 4.7 cm; P = .002), 6-minute walking distance (6MWD) (501.1 ± 69.3 vs 535.3 ± 65.6 m; P = .03), and maximal oxygen uptake (VO2max) (29.7 ± 4.7 vs 31.9 ± 4.6 mL/kg/min; P = .02). One-year GHRT led to reduced sitting time (3107.5 ± 1370.9 min/wk; P = .03), WtHR (0.45 ± 0.06; P = .02) and fat mass percentage (27.4 ± 5.4 vs 23.7 ± 5.8; P < .0001), increased METs-min/wk (2174.5 ± 1737.9 vs 2788.1 ± 2395.0; P = .05), fat-free mass (22.1 ± 7.6 vs 27.9 ± 9.4 kg; P < .0001), handgrip strength (11.1 ± 3.6 vs 15.4 ± 4.9 kg; P = .0001) squat jump (16.6 ± 4.7 cm; P = .01), long jump (129.6 ± 25.2 cm; P < .0001), countermovement jump (16.0 ± 4.3 cm; P = .003), 6MWD (540.5 ± 88.5 m; P = .01), VO2max (31.8 ± 5.1 mL/kg/min, P = .02), and physical (76.76 ± 16.42 vs 84.61 ± 11.63; P < .007) and psychosocial HRQoL scores (75.61 ± 15.12 vs 80.91 ± 11.12; P < .05).
conclusionGHRT exerts broad beneficial effects on health-related physical fitness and HRQoL in children with GHD.
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