Trial reportMultiple sclerosis (Houndmills, Basingstoke, England)2026
Contribution of structural and functional MRI in predicting response to motor training in multiple sclerosis.
Trial report in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
backgroundAerobic training is a promising rehabilitation strategy in multiple sclerosis (MS). However, individual responses to exercise vary.
objectivesTo assess whether baseline demographic, clinical, and MRI features in MS patients predict response to aerobic or non-aerobic training.
methodsEighty-eight MS patients were randomized to 24-session aerobic (
resultsThirty-four MS patients (aerobic = 20, non-aerobic = 14) were responders. Predictors of treatment response were corticospinal tract (CST) and middle cerebellar peduncle (MCP) fractional anisotropy in the aerobic group and superior cerebellar peduncle (SCP) mean diffusivity in the non-aerobic group. SCP, MCP, and CST diffusivity metrics predicted training response in whole MS cohort. Repeated cross-validation confirmed identified predictors relevance (median area under the curve from 0.648 to 0.672).
conclusionMicrostructural integrity of motor-related WM tracts predicts training response in MS, highlighting the role of neuroimaging in identifying patients likely to benefit from rehabilitation.
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