Enhancing apple disease resistance via magnetic nanoparticle-mediated delivery of artificial miRNAs that suppress a tRNA-derived small RNA targeting a disease-resistant gene.

Qiulei Zhang, Feiyu Liu, Qingqing Guo, Jinqi Tang, Tianzhong Li

Abstract read

In one paragraph

Article in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Qiulei ZhangLaboratory of Fruit Cell and Molecular Breeding, China Agricultural University, Beijing 100193, China.

Feiyu LiuLaboratory of Fruit Cell and Molecular Breeding, China Agricultural University, Beijing 100193, China.

Qingqing GuoLaboratory of Fruit Cell and Molecular Breeding, China Agricultural University, Beijing 100193, China.

Jinqi TangLaboratory of Fruit Cell and Molecular Breeding, China Agricultural University, Beijing 100193, China.

Tianzhong LiLaboratory of Fruit Cell and Molecular Breeding, China Agricultural University, Beijing 100193, China. Electronic address: litianzhong1535@163.com.

Funding

Non-US Government Research Support type

6 · The paper itself

Abstract

Apple early defoliation disease poses a serious threat to the sustainability of global apple production, causing substantial yield losses and reduced fruit quality. Chemical fungicides remain the primary means of disease control; however, their excessive use leads to environmental pollution and food safety concerns. Here, we identified a pathogen-induced tRNA-derived small RNA (tsRVal) that targets the disease-resistance gene Malus domestica TRANSPORT INHIBITOR RESPONSE 1 (MdTIR-1), thereby modulating apple susceptibility to early defoliation disease. To suppress tsRVal accumulation, we designed an artificial miRNA (si-tsRVal) and loaded it onto Fe

Indexed as

Disease ResistanceMagnetite NanoparticlesMalusMicroRNAsPlant DiseasesRNA, TransferRNA, PlantMagnetite NanoparticlesMicroRNAsRNA, PlantRNA, Transferappleapple early defoliation diseasenanobiotechnologyRNA interference

Identifiers

PMID41420331

DOI10.1016/j.xplc.2025.101681

PMCPMC12983263

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Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.