Evidence map›Paper›PMID 41420274›Full record

ArticlePlant biotechnology journal2026

Plastid Engineering for Photosynthesis-Driven Synthesis of Hyaluronic Acid in Tobacco.

Amanda Lopes, Omar Sandoval-Ibáñez, Stéphanie Arrivault, David Rolo, F Vanessa Loiacono, Alexander Erban, Daniel Karcher, Stephan Obst, Stephanie Ruf, Joachim Kopka and 1 more

Abstract read
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amanda LopesMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0002-1164-9521
Omar Sandoval-IbáñezMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0002-4513-1704
Stéphanie ArrivaultMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0003-0516-6950
David RoloMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0002-5756-4849
F Vanessa LoiaconoMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0001-8210-1216
Alexander ErbanMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0003-1794-588X
Daniel KarcherMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0001-6393-7376
Stephan ObstMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.
Stephanie RufMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0002-9469-5944
Joachim KopkaMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.ORCID https://orcid.org/0000-0001-9675-4883
Ralph BockMax-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam-Golm, Germany.

Funding

Alexander von Humboldt Foundation, Bonn, GermanyCoordination of Superior Level Staff Improvement (CAPES), BrazilMax-Planck-Gesellschaft
6 · The paper itself

Abstract

Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N-acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes. Current synthesis of HA polymers relies on microorganisms and requires supply of glucose in bioreactors to produce glucose-6-phosphate and fructose-6-phosphate as precursors for HA biosynthesis. By contrast, photosynthetic organisms generate glucose-6-phosphate and fructose-6-phosphate as autotrophic products of CO

Indexed as

Hyaluronic AcidNicotianaPhotosynthesisPlastidsChloroplastsGenetic EngineeringPlants, Genetically ModifiedHyaluronic Acidchloroplasthyaluronic acidmetabolic engineeringNicotiana tabacumplastidplastid transformationsynthetic operon

Identifiers

PMID41420274
PMCPMC13140457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.