Evidence map›Paper›PMID 41420203›Full record

ArticleBMC microbiology2025

Genomic epidemiology of antimicrobial resistance in Proteus mirabilis: core genome and plasmid-mediated drivers.

Peng Zhang, Zhikang Cheng, Yang Cao, Shuangqing Liu, Meiqi Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peng ZhangAnhui Province Key Laboratory of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. zpeng@email.tjut.edu.cn.
Zhikang ChengTianjin Key Laboratory of Life and Health Detection, Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, 300384, China.
Yang CaoDepartment of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
Shuangqing LiuDepartment of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China. liushuangqing@tmu.edu.cn.
Meiqi ZhaoDepartment of gastroenterology &hepatology, Tianjin First Center Hospital, Tianjin, 300192, China. meiqizhao@mail.nankai.edu.cn.

Funding

National Natural Science Foundation of China 32201393
6 · The paper itself

Abstract

Proteus mirabilis has emerged as a clinically significant multidrug-resistant (MDR) pathogen, yet the genomic drivers and dissemination mechanisms of its antimicrobial resistance (AMR) remain poorly characterized. To address this gap, we conducted a pangenome analysis of 2,013 P. mirabilis genomes, including 1,990 publicly available strains and 23 newly sequenced clinical isolates, to delineate the species-wide AMR landscape. Our study identified 197 AMR gene subtypes spanning 12 antibiotic classes, with seven resistance determinants embedded in the core genome. Clinically critical resistance phenotypes-notably to third-generation cephalosporins and carbapenems-were strongly associated with the proliferation of β-lactamase genes (bla

Indexed as

Drug Resistance, Multiple, BacterialGenome, BacterialPlasmidsProteus InfectionsProteus mirabilisAnti-Bacterial Agentsbeta-LactamasesGenomicsHumansMicrobial Sensitivity TestsMolecular EpidemiologyPhylogenyAnti-Bacterial Agentsbeta-LactamasesAMR transmissionAntimicrobial resistancePlasmidProteus mirabilis

Identifiers

PMID41420203
PMCPMC12874753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.