Evidence map›Paper›PMID 41420120›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

PET imaging of cardiac sympathetic nervous system dysfunction using meta-[

Uzair S Ismailani, Ariel Buchler, Jadde de Carvalho Tso, Serena M Pulente, Faduma Abdirahman, Emily L Hoddinott, Megan Fortier, Erin E Mulvihill, Robert A deKemp, Benjamin H Rotstein

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Uzair S IsmailaniDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.ORCID 0000-0001-5102-6102
Ariel BuchlerUniversity of Ottawa Heart Institute, Ottawa, Canada.ORCID 0000-0002-4016-032X
Jadde de Carvalho TsoUniversity of Ottawa Heart Institute, Ottawa, Canada.
Serena M PulenteDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.ORCID 0000-0002-4837-6790
Faduma AbdirahmanUniversity of Ottawa Heart Institute, Ottawa, Canada.ORCID 0000-0002-8396-1186
Emily L HoddinottUniversity of Ottawa Heart Institute, Ottawa, Canada.ORCID 0009-0003-0355-9184
Megan FortierUniversity of Ottawa Heart Institute, Ottawa, Canada.
Erin E MulvihillDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada.ORCID 0000-0002-3981-0241
Robert A deKempUniversity of Ottawa Heart Institute, Ottawa, Canada.
Benjamin H RotsteinDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada. benjamin.rotstein@uottawa.ca.ORCID 0000-0001-9707-9357

Funding

Canada Foundation for Innovation 39358Heart and Stroke Foundation of Canada G-23-0035462
6 · The paper itself

Abstract

purposeCardiac sympathetic nervous system (SNS) dysfunction is a hallmark of and contributor to the development of heart failure (HF) and cardiac arrhythmias. Positron emission tomography (PET) radiotracers targeting the norepinephrine transporter (NET) have demonstrated utility in assessing global and regional cardiac sympathetic innervation. To date, the scarcity of fluorine-18 containing SNS radiotracers demonstrating NET dependency in rodents has precluded research in commonly used preclinical cardiac disease models. We demonstrate the utility of [

methodsDSS cohorts were fed a low salt (LS) or an HS diet for 21-weeks. Serial echocardiography imaging was performed to assess cardiac function. PET imaging was conducted every four weeks to measure [

resultsDeclining cardiac function in the presence of hypertension was observed in rats kept on HS diet for 4-weeks (HS-4) and worsened in HS-16 rats. Concomitant with hemodynamic instability, 32% reduced peak uptake in the LV was noted by [

conclusion[

Indexed as

GuanidinesHeartPositron-Emission TomographySympathetic Nervous SystemAnimalsFluorine RadioisotopesMaleNorepinephrine Plasma Membrane Transport ProteinsRadiopharmaceuticalsRatsRats, Inbred DahlRats, Sprague-DawleyFluorine RadioisotopesGuanidinesNorepinephrine Plasma Membrane Transport ProteinsRadiopharmaceuticalsAutonomic dysfunctionCardiac sympathetic dysfunctionFluorine-18Heart failureNorepinephrine transporterPositron emission tomographySympathetic nerve imaging

Identifiers

PMID41420120

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.