ArticleCell death and differentiation2026
MTF1 attenuates ferroptosis and cuproptosis synergistic potentiation in gastric cancer.
Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis.Cancer biology & therapy · 2026Article
- Reprogramming of cell death in gastric cancer: From molecular mechanisms to therapeutic potential (Review).International journal of molecular medicine · 2026Review
- The Spatial Redox-Metalloptosis Axis in Liver Disease: A Hypothesis on Regional Susceptibility to Ferroptosis and Cuproptosis.Antioxidants (Basel, Switzerland) · 2026Review
- Cuproptosis: an emerging member of the immunogenic cell death family.Cell death and differentiation · 2026Article
- EP300-Mediated MTF1-K218 Lactylation Buffers AR-Driven Copper Overload to Suppress Cuproptosis in Castration-Resistant Prostate Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Redox-regulated cell death in gastric cancer: Molecular insights and therapeutic opportunities.Journal of physiology and biochemistry · 2026Review
- Metal overload synergy induces cell death in gastric cancer.Cell death and differentiation · 2026Article
- Exploring dysregulation of cuproptosis-related genes molecular clusters and candidate biomarkers in pterygium.Scientific reports · 2026Article
- Geno-guided targeting of ferroptosis: a multi-layered network to overcome radioresistance in lung cancer.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The recent discovery of cell death mediated by metal ions has aroused significant interest in harnessing this novel mechanism of cell death for cancer therapy. As the two identified metal ion-based regulated cell death forms, ferroptosis and cuproptosis were initially studied separately, while increasing evidences underscored their intricate connections. Gastric cancer (GC) is one of the most severe malignant tumors of the digestive system. Targeting the complex interplay between ferroptosis and cuproptosis, and understanding their intrinsic mechanisms may offer approaches for developing innovative therapies in GC. Here, we identified that metal-regulatory transcription factor 1 (MTF1) was the key gene blocking the sensitivity of ferroptosis and cuproptosis enhanced by the combination treatment with FINO2 and ES-Cu in vitro and in vivo. Mechanistically, MTF1 suppressed FINO2/ES-Cu induced ferroptosis through upregulating FTH1 to reduce Fe
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.