Evidence map›Paper›PMID 41420083›Full record

ArticleScientific reports2025

Cannabidiol-based lipid nanocarriers with analgesic activity.

Arissa de Oliveira Sato, João Pedro Tánnus Goulart, Tamiris Sabrina Rodrigues, Carlos Ueira-Vieira, Luciana Machado Bastos, Simone Sommerfeld, Belchiolina Beatriz Fonseca, Lígia Nunes de Morais Ribeiro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arissa de Oliveira SatoInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
João Pedro Tánnus GoulartInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Tamiris Sabrina RodriguesInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Carlos Ueira-VieiraInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Luciana Machado BastosInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Simone SommerfeldSchool of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil.
Belchiolina Beatriz FonsecaInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil.
Lígia Nunes de Morais RibeiroInstitute of Biotechnology, Federal University of Uberlândia, Uberlândia, Brazil. ligia.ribeiro@ufu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain remains a major clinical challenge due to its complex and multifactorial nature. The available treatments, such as conventional analgesics and opioids, often fail to provide adequate relief and are associated with limitations, including cardiovascular toxicity and short duration of action. This scenario reinforces the urgent need for safer and more effective therapeutic approaches. Cannabidiol (CBD) has emerged as a promising alternative in the pain management. Nanoencapsulation based on nanostructured lipid carriers (NLC) offers a potential strategy to overcome these limitations. In this work, CBD oil was encapsulated in NLC (NLC/CBD; 5.0%), resulting in a formulation that remained stable for 365 days at 25 °C. In vivo tests using chicken embryos indicated no toxicity of NLC/CBD at concentrations ranging from 0.72 to 2.87 mg/mL. Furthermore, the analgesia of NLC/CBD (1.0 mg/mL) was confirmed on Drosophila melanogaster alternative biological model. These findings suggested that the herbal-based NLC loading CBD could represent a cheap, long-term stable, biocompatible and efficient nanosystem for pain management.

Indexed as

AnalgesicsCannabidiolDrug CarriersLipidsNanoparticlesAnimalsChick EmbryoDrosophila melanogasterNanostructuresPainAnalgesicsCannabidiolDrug CarriersLipidsAnalgesiaCannabidiolNanostructured lipid carriersNatural lipidsPain

Identifiers

PMID41420083
PMCPMC12835139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.