ReviewDermatologie (Heidelberg, Germany)2026
[Per- and polyfluoroalkyl substances-"forever chemicals" and skin].
Review in Dermatologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPer- and polyfluoroalkyl substances (PFAS) are a large group of anthropogenic chemicals that have been widely used in industrial manufacturing for decades. Due to their persistence in both the biotic and abiotic environment over many years, PFAS are also referred to as "forever chemicals." Some PFAS exhibit toxic properties and can harm both the environment and human health.
objectiveTo describe the chemical properties, adverse health effects, and main exposure sources of PFAS, with a particular focus on the skin and inflammatory skin diseases. MATERIALS AND
methodsAn unrestricted literature search was conducted in PubMed and Google Scholar to prepare a narrative review. The search terms included the following: atopic dermatitis, cutaneous, forever chemicals, PFAS, PFOA, psoriasis, skin, skin cancer, skin disease.
resultsHuman skin exposure to PFAS occurs either through direct contact with contaminated cosmetics, personal care products, and textiles, or indirectly through the redistribution of systemically absorbed PFAS. Depending on the specific PFAS compound, as well as the duration and level of exposure, these substances can suppress cutaneous immune responses, induce oxidative stress, and trigger proinflammatory tissue reactions. Epidemiological studies have shown an association between PFAS exposure and atopic dermatitis, particularly among female study participants.
conclusionThe currently available epidemiological and experimental evidence regarding the effects of PFAS on skin health remains limited in scope and strength. Given the near-ubiquitous presence of PFAS in the environment, further research is urgently needed to better understand the associated risks to the skin and to develop targeted preventive strategies.
Indexed as
Identifiers
41420066What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.