ArticleDiscover oncology2025
Hotspots and frontiers of the relationship between hepatocellular carcinoma and cancer-associated fibroblasts: a bibliometric analysis and review.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
backgroundCancer-associated fibroblasts (CAFs) are pivotal stromal components in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC), influencing tumor progression, metastasis, and immunotherapy resistance. However, a comprehensive bibliometric overview of CAFs in HCC is lacking.
methodsA systematic search of the Web of Science Core Collection from January 1, 2004, to June 15, 2025 yielded 646 eligible publications. Bibliometric analysis using VOSviewer and CiteSpace mapped publication trends, international collaboration, institutional contributions, author networks, journal impact, and research hotspots.
resultsA total of 646 articles were analyzed, spanning 282 journals and 2684 keywords. From 2004 to June 15, 2025, there was a significant increase in publications. China led in publication numbers, followed by the US and Japan. Renowned institutions include Sun Yat Sen University, Fudan University, and Zhejiang University. Notable researchers are Fan Jia, Giannelli Gianluigi, and Zhou Jian. The journal with the highest publication and citation frequency is Cancer Research. The main research focuses are the effects of CAFs on HCC cell proliferation, angiogenesis, invasion, metastasis, immunosuppression, and drug resistance, as well as the mechanisms of CAFs in HCC immunotherapy and the progress in targeted CAF research.
conclusionCAFs research in HCC has transitioned from descriptive studies to precision therapeutic targeting. Future directions involve dissecting CAFs plasticity, leveraging single-cell multiomics, and optimizing combination therapies to overcome TME-mediated resistance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.