Evidence map›Paper›PMID 41419938›Full record

ArticleParticle and fibre toxicology2025

Impact of surface functional group modification on cellular internalization and cytotoxicity of silica nanoparticles.

Sandra Vranic, Eri Watanabe, Kyoka Yamazaki, Takatsugu Wakahara, Kayoko Miyakawa, Sakie Takeuchi, Yurika Osada, Sahoko Ichihara, Wenting Wu, Cai Zong and 11 more

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sandra VranicDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Eri WatanabeDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Kyoka YamazakiDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Takatsugu WakaharaNational Institute of Materials Science, Tsukuba, Japan.
Kayoko MiyakawaDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Sakie TakeuchiDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Yurika OsadaDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Sahoko IchiharaJichi Medical University School of Medicine, Shimotsuke, Japan.
Wenting WuDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Cai ZongDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Toshihiro SakuraiDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan.
Akira SatoDepartment of Biochemistry and Molecular Biology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Yasushi HaraResearch Institute of Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Akihiko IkegamiJichi Medical University School of Medicine, Shimotsuke, Japan.
Yuya TerashimaResearch Institute of Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Kouji MatsushimaResearch Institute of Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Toshihiro SuzukiResearch Institute of Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Ryo AbeResearch Institute of Biomedical Sciences, Tokyo University of Science, Noda, Japan.
Sonja BolandUniversité Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, 75013, Paris, France.
Lang TranInstitute of Occupational Medicine, Edinburgh, UK.
Gaku IchiharaDepartment of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Tokyo, 125-8585, Japan. gak@rs.tus.ac.jp.

Funding

Japan Society for the Promotion of Science #PE13040JSPS LS056
6 · The paper itself

Abstract

backgroundSilica nanoparticles (SiO

methodsIn the in vivo arm of the study, male mice were randomly divided into seven groups (n = 6, each) and exposed to either amino (NH

resultsThe in vivo studies demonstrated significant increase in lung weight at 2 and 10 mg/kg bw by OH-SiO

conclusionNH

Indexed as

MacrophagesNanoparticlesSilicon DioxideAnimalsAutophagyBronchoalveolar Lavage FluidCell SurvivalLungMaleMiceRAW 264.7 CellsRhodaminesSurface PropertiesRhodaminesSilicon Dioxide

Identifiers

PMID41419938
PMCPMC12950232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.