Evidence map›Paper›PMID 41419897›Full record

SynthesisBMC surgery2025

Efficacy and safety of tranexamic acid during bariatric surgery: an updated systematic review and meta-analysis of 10 comparative studies.

Ahmed Abu-Zaid, Monirah Khaled Alotaibi, Fajer N Hasan, Hadeel A Alkandari, Sara Almutawtah, Bader N Almutawaa, Mohammad Salem Alajmi, Fahad N Aladwani, Lulwah A Alselahy, Fatemah A Ali and 3 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed Abu-ZaidDepartment of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. amabuzaid@alfaisal.edu.ORCID http://orcid.org/0000-0003-2286-2181
Monirah Khaled AlotaibiKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Fajer N HasanKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Hadeel A AlkandariCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.
Sara AlmutawtahKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Bader N AlmutawaaKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Mohammad Salem AlajmiFaculty of Medicine and Health Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Fahad N AladwaniFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.
Lulwah A AlselahyRoyal College of Surgeons in Ireland, Busaiteen, Kingdom of Bahrain.
Fatemah A AliCollege of Medicine, Kuwait University, Kuwait City, Kuwait.
Sarah Saqer AlblooshiKuwait Institute for Medical Specializations, Kuwait City, Kuwait.
Hessa Mohammed AlfayadhCollege of Medicine, Almaarefa University, Riyadh, Saudi Arabia.
Abdullah M AlharranCollege of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to conduct an updated systematic review and meta-analysis of comparative studies evaluating the efficacy and safety of tranexamic acid (TXA) during bariatric surgery.

methodsSix databases were searched up to September 2, 2025. The primary endpoint was the rate of postoperative bleeding. Secondary endpoints included transfusion, hematoma, reoperation, thromboembolic events, operative time, and hospital stay. Outcomes were pooled as risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CI) using a random-effects model.

resultsTen studies (11 treatment arms; 2,137 patients, mostly undergoing laparoscopic sleeve gastrectomy) were included. TXA, usually given as a single intravenous dose at induction, was associated with a lower risk of postoperative bleeding (9 studies; RR 0.57, 95% CI 0.36–0.88), although this effect was not robust in leave-one-out sensitivity analyses. No significant differences were observed for blood transfusion, hematoma, or reoperation. TXA modestly reduced operative time and length of stay, but these differences were not clinically important. No thromboembolic events were reported in TXA-treated patients, and overall risk of bias was judged as low to moderate across most studies.

conclusionTXA may reduce postoperative bleeding, but the effect was not robust in sensitivity analyses; though further high-quality RCTs are needed.

Indexed as

Antifibrinolytic AgentsBariatric SurgeryPostoperative HemorrhageTranexamic AcidHumansTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidBariatric surgeryBleedingLaparoscopic sleeve gastrectomyMeta-analysisTranexamic acid

Identifiers

PMID41419897
PMCPMC12831442

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.