Evidence map›Paper›PMID 41419895›Full record

ArticleJournal of nanobiotechnology2025

Hierarchical chirality of bone cement drives osteoinduction via integrin dependent signaling to accelerate critical bone defect regeneration.

Jinzhou Du, Liang Yang, Lingchi Kong, Tengfei Lou, Ai Yang, Chao Zhou, Yun Qian, Cunyi Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinzhou Du *Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Liang Yang *Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Lingchi Kong *Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Tengfei LouDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Ai YangDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
Chao ZhouDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. super_zhou@shsmu.edu.cn.
Yun QianDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. sakio@sjtu.edu.cn.
Cunyi FanDepartment of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. cyfan@sjtu.edu.cn.

Funding

Clinical Research Plan of SHDC SHDC2023CRT011Emerging Interdisciplinary Research Program of Shanghai Municipal Health Commission 2022JC035National Natural Science Foundation of China 82402770National Natural Science Foundation of China,China 82402791
6 · The paper itself

Abstract

The biocompatibility and degradability of calcium phosphate bone cement (CPC) make it a potential therapeutic strategy to critical bone defects repair. However, it fails to create a stable extracellular microenvironment for inducing stem cells osteogenic differentiation, which hinders the wider clinical application. Receiving inspiration from chiral structures in biological organisms, particularly skeleton, we incorporated hierarchical chiral hydroxyapatite (CHA) into CPC to fabricate the microenvironment conducive to bone repair. Interestingly, levorotatory hydroxyapatite (LH) cement significantly enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs), followed by racemic hydroxyapatite (RH) cement. Whereas dextral hydroxyapatite (DH) and achiral hydroxyapatite (HA) cement didn't display a comparable effect. The differentiated osteoblasts and osteogenic proteins on the LH cement continuously recruited stem cells, facilitating the construction of osteoinductive microenvironment. Regard to the underlying mechanism, LH bone cement tightly bound to integrin α9, thereby facilitating the activation of PI3K/AKT pathway and enhancing the expression of osteogenic transcription factors. Following the implantation of LH bone cement into femur defect of rabbits, it exhibited good biocompatibility, enhanced the vascularization of bone defect region, and accelerated new bone formation effectively.

Indexed as

Bone CementsBone RegenerationIntegrinsOsteogenesisAnimalsBiocompatible MaterialsCalcium PhosphatesCell DifferentiationCells, CulturedDurapatiteFemurHumansMesenchymal Stem CellsOsteoblastsRabbitsSignal TransductionBiocompatible MaterialsBone CementsCalcium PhosphatesDurapatiteIntegrinsBone marrow mesenchymal stem cellChiralityCritical bone defect repairHydroxyapatiteOsteoinductivity

Identifiers

PMID41419895
PMCPMC12717770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.