Evidence map›Paper›PMID 41419857›Full record

ArticleBMC infectious diseases2025

Standardized vaccination practices for preterm infants: Egyptian experts' consensus.

Ahmed El Beleidy, Mohamed Ghandour, Adel Reyad, Amira Edris, Gamal Samy, Hesham Abdel-Hady, Hisham Awad, Khalil AbdelKhalek, Mostafa El-Saied, Mohamed Omar and 8 more

Abstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Ahmed El BeleidyPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt. ahmed.elbeleidy@kasralainy.edu.eg.
Mohamed GhandourDepartment of Pediatrics, City Clinic, Cairo, Egypt.
Adel ReyadPediatrics and Neonatology Department, Benha University, Benha, Egypt.
Amira EdrisPediatrics and Neonatology, Kasr El Aini Hospital, Cairo University, Cairo, Egypt.
Gamal SamyFaculty of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt.
Hesham Abdel-HadyDepartment of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Hisham AwadPediatrics and Neonatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Khalil AbdelKhalekPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Mostafa El-SaiedPediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Mohamed OmarPediatric Consultant and Senior Consultant of the General Administration of Medical Affairs, Helwan University, Cairo, Egypt.
Moataza BashirPediatrics and Neonatology, Kasr El Aini Hospital, Cairo University, Cairo, Egypt.
Mourad Alfy TadrosMilitary Medical Academy, Armed Forces College of Medicine, Cairo, Egypt.
Mostafa MohammadyVaccination Centers in Egyptian Holding Company for Biological Products and Vaccines (VACSERA), Giza, Egypt.
Noha GebrilHead of Pediatrics and Neonatology Department in Alexandria, New Medical Center (ANMC), Alexandria, Egypt.
Ranya Aly HegazyPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Safaa Shafik ImamNeonatology Department, Ain Shams University Hospital, Ain Shams University, Cairo, Egypt.
Sherif ElanwaryPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Walaa Adel MansourVaccination Centers in Egyptian Holding Company for Biological Products and Vaccines (VACSERA), Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreterm birth has become increasingly common over the past several decades. The underdeveloped immune systems place preterm infants at an increased risk of infections, often vaccine-preventable, compared to full-term infants. Despite the importance of immunizing preterm infants, research on vaccine safety, immunogenicity, and effectiveness in this population remains limited. This consensus article seeks to provide clear, evidence-based recommendations to improve vaccine coverage and timely immunization in preterm infants in Egypt.

methodsA modified Delphi consensus approach was employed to develop evidence-based recommendations for preterm infant vaccination in Egypt. A panel of 18 experts, including pediatricians, neonatologists, and a pharmacist participated. The process covered 15 key vaccination topics, with 59 statements formulated based on a comprehensive literature review. A 5-point Likert scale was used to evaluate the statements, with ≥ 70% agreement threshold for consensus. Statements not meeting this threshold were revised and subjected to a second voting round. Final recommendations were established based on the achieved consensus.

resultsOur consensus included 59 statements. In the first round of voting, 63 statements were evaluated, with the panel reaching a consensus on 54 statements. Nine statements fell below the 70% agreement threshold and required a second round of voting. A second round was conducted, including these nine statements along with one newly added statement. Ultimately, five statements achieved consensus, while five were removed.

conclusionEstablishing preterm vaccination guidelines is important for reducing mortality and morbidity in this high-risk population, especially in Egypt. This consensus emphasizes the need for timely immunization to minimize the risk of infections associated with delayed vaccination. Additionally, it identifies several areas requiring further research, ensuring that future updates can continue to refine and enhance immunization strategies for preterm infants. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Infant, PrematureVaccinationVaccinesDelphi TechniqueEgyptHumansInfant, NewbornVaccinesEgyptImmunizationLow birth weightPrematurePretermVaccinationVaccination scheduleVaccine

Identifiers

PMID41419857
PMCPMC12831249

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