ArticleScientific reports2025
HIV/AIDS compartmental model analysis with drug resistance treatment, vertical transmission, and optimal control theory.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
This study develops a novel HIV/AIDS compartmental model that integrates the critical, interconnected challenges of drug resistance emergence from treated individuals, healthcare constraints via a saturating treatment function, and persistent vertical transmission. The objective is to provide a comprehensive mathematical framework for analyzing these complex dynamics and designing effective intervention strategies. Our analysis reveals that treatment saturation can induce a backward bifurcation, complicating disease eradication efforts, while optimal control simulations demonstrate that a combined strategy of enhanced screening, accelerated treatment initiation, and adherence support significantly reduces infection pools and minimizes disease progression compared to isolated interventions.
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