In one paragraphArticle in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Bingchen Du *State Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0009-0002-1317-8249 Bingyu ZhaoState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0009-0009-1977-9716 Zhibin ShiState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0000-0003-1671-3876 Zaisi LiuState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0009-0008-0385-5465 Shida WangState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0009-0004-2274-2627 Lili WeiState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0009-0005-2465-4660 Xijun HeState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China.ORCID http://orcid.org/0000-0002-0427-6405 Decheng YangState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China. yangdecheng@caas.cn.ORCID http://orcid.org/0000-0003-1279-7136 Jingfei WangState Key Laboratory for Animal Disease Control and Prevention & Data Center for Field Scientific Observation and Research of Animal Diseases, Ministry of Agriculture and Rural Affair, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, PR China. wangjingfei@caas.cn.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) serve as entry receptors for the Semliki Forest virus (SFV). VLDLR interacts with the SFV E1 domain III (DIII) through multiple LDLR class A (LA) domains. However, the ApoER2-mediated SFV entry mechanism remains unclear. Here, we perform biochemical and cellular results and determine the cryogenic electron microscopy (cryo-EM) structures of SFV complexed with ApoER2 LA5 and full-length ApoER2, demonstrating that among the seven LA domains of ApoER2 isoform 1, only LA5 specifically binds to the SFV E1-DIII via a limited interface (353 Ų) and facilitates cell attachment and entry. Site-directed mutagenesis confirms the significance of the residues at the SFV-ApoER2 interface. Significantly, a soluble LA5 decoy receptor neutralizes SFV infection and protects mice from lethal SFV challenge. These findings reveal a LA5-dependent receptor engagement mechanism for SFV entry via ApoER2, distinct from VLDLR.
Indexed as
Receptors, LDLReceptors, LipoproteinSemliki forest virusVirus InternalizationAnimalsCryoelectron MicroscopyHEK293 CellsHumansLDL-Receptor Related ProteinsMiceMutagenesis, Site-DirectedProtein BindingProtein DomainsLDL-Receptor Related Proteinslow density lipoprotein receptor-related protein 8Receptors, LDLReceptors, Lipoprotein
Identifiers
PMID41419770
PMCPMC12827466
What OpenQuestion holds
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LicenceCC BY-NC-ND
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