ArticleNPJ vaccines2025
Immunogenicity of one and two doses of Gardasil®9 in Tanzanian girls in the DoRIS Trial.
Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02834637 (A Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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A Dose Reduction Immunobridging and Safety Study of Two HPV Vaccines in Tanzanian Girls
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Authors and funding
12 authors.
Funding
Abstract
Tanzanian girls received one to three doses of Gardasil®9 in the DoRIS randomised trial. Blood samples from one and two-dose Gardasil®9 recipients were collected at months (M)0, M7, M12, M24, and M36 for testing via an HPV Multiplex immunoassay. All participants were HPV 16, HPV 31, and HPV 58 seropositive at M36. For the one-dose group, 96.8-98.2% of girls were seropositive for HPV 11, HPV 18, and HPV 33 and 73.0-87.7% seropositive for HPV 6, HPV 45 and HPV 52. For the two-dose group, all participants were HPV 6, HPV 11, HPV 18, and HPV 33 seropositive, while 98.6% seropositive for HPV 45 and HPV 52. Geometric mean concentrations (GMCs) were higher in the two-dose group compared to the one-dose group but all GMCs in the one-dose group had plateaued by M24 and remained stable to M36. HPV vaccine immune responses in this study will continue through nine years post-vaccination. ClinicalTrials.gov ID: NCT02834637; Registration Date: 2016-06-29; https://www.clinicaltrials.gov/study/NCT02834637 .
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