Evidence map›Paper›PMID 41419726›Full record

ArticleUpdates in surgery2026

The impact of socio-economic disparities on kidney transplant outcomes: insights from a monocentric Italian study.

Quirino Lai, Fabio Melandro, Luca Poli, Mario Piazzolla, Fatima Della Pietra, Veronica Zullino, Giulia Diamantini, Matteo Brisciani, Silvia Quaresima, Massimo Rossi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Quirino LaiGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy. lai.quirino@libero.it.ORCID http://orcid.org/0000-0003-1487-3235
Fabio MelandroGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Luca PoliGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Mario PiazzollaDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Fatima Della PietraGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Veronica ZullinoDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Giulia DiamantiniGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Matteo BriscianiDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Silvia QuaresimaGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Massimo RossiGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.
Francesco PuglieseDepartment of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy.
Manuela GarofaloGeneral Surgery and Organ Transplantation Unit, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplantation (KT) is the preferred treatment for end-stage renal disease (ESRD), but socio-economic disparities significantly influence access to transplantation, waiting list (WL) outcomes, and post-transplant results. This study evaluates the impact of the socio-economic deprivation index (SEDI) on WL and KT outcomes in an Italian center. This monocentric, retrospective cohort study analyzed 1560 adult patients enlisted for KT at Sapienza University of Rome (2000-2024). Socio-economic and clinical data were collected, and patients were stratified into low-SEDI and high-SEDI groups. The primary outcome was a composite of death and WL drop-out due to clinical worsening. Secondary outcomes included post-transplant graft loss. Kaplan-Meier survival analysis and Cox regression models were used to evaluate risk factors. Patients in high-SEDI areas had longer times from dialysis initiation to WL inscription (27 vs. 20 months, P < 0.001) and from WL inscription to transplantation (22 vs. 17 months, P < 0.001). The composite outcome of death or WL drop-out occurred in 8.7% of patients, with no significant differences between SEDI groups. However, high-SEDI patients faced significantly higher risks of post-transplant graft loss due to socio-economic factors, including vulnerable housing conditions and demographic disparities. Multivariable Cox analysis identified dialysis-to-WL duration and socio-economic factors as significant predictors of WL and post-transplant outcomes. Socio-economic factors, as measured by SEDI, significantly influence WL and KT outcomes, underscoring the need for targeted interventions to minimize delays and improve access in high-SEDI regions. Strategies such as early referral, live donor promotion, and equitable healthcare access are crucial for optimizing KT outcomes.

Indexed as

Healthcare DisparitiesKidney Failure, ChronicKidney TransplantationSocioeconomic FactorsAdultFemaleGraft SurvivalHumansItalyMaleMiddle AgedRetrospective StudiesRisk FactorsSocioeconomic Disparities in HealthTreatment OutcomeWaiting ListsDeprivation indexLiving donorPost-transplant careRegional disparitiesWaiting list

Identifiers

PMID41419726
PMCPMC13538254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.