Evidence map›Paper›PMID 41419656›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Evaluating the accuracy of point of care testing compared to standard laboratory testing among inborn infants in the neonatal intensive care unit.

Isha Parikh, Sepideh Saroukhani, Matthew Rysavy, Brian Chang, Mar Romero-Lopez, Lindsay F Holzapfel

Abstract readComparative Study
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Isha ParikhDivision of Neonatal-Perinatal Medicine, Dept. of Pediatrics, McGovern Medical School, Houston, TX, USA.
Sepideh SaroukhaniDivision of Clinical and Translational Sciences, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Matthew RysavyDivision of Neonatal-Perinatal Medicine, Dept. of Pediatrics, McGovern Medical School, Houston, TX, USA.ORCID http://orcid.org/0000-0002-1209-6607
Brian ChangDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Mar Romero-LopezDivision of Neonatal-Perinatal Medicine, Dept. of Pediatrics, McGovern Medical School, Houston, TX, USA.ORCID http://orcid.org/0000-0002-5890-7786
Lindsay F HolzapfelDivision of Neonatal-Perinatal Medicine, Dept. of Pediatrics, McGovern Medical School, Houston, TX, USA. lindsay.n.fleig@uth.tmc.edu.ORCID http://orcid.org/0000-0002-1830-5705

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
Center for Clinical and Translational SciencesUM1TR004906 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Maria Eulalia Fernandez, LORNA H. MCNEILL · 2024 to 2026
$16.7M
NCATS NIH HHS UL1 TR003167NCATS NIH HHS UM1 TR004906NICHD NIH HHS L40 HD109887U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) 1UM1TR004906-01
6 · The paper itself

Abstract

objectivePoint-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly for low-birth-weight infants.

methodsA retrospective cohort included 118 patients with paired POC and CL tests within one hour in the first 14 postnatal days. Differences and agreement were assessed using linear mixed-effect models that account for within and between-subject variations.

resultsCompared to CL, POC testing underestimated sodium (6.0 mEq/L), potassium (0.1 mEq/L), chloride (5.1 mEq/L), and glucose (2.3 mg/dL), and overestimated hemoglobin (0.08 g/dL) and hematocrit (0.8%). Differences (CL- POC) varied by postnatal age and sample type, with larger differences for sodium and chloride that decreased with age and smaller differences in capillary and venous than arterial samples. Glucose and hemoglobin differences increased over time, while hematocrit remained stable.

conclusionsPOC results underestimated sodium, potassium, chloride, and glucose, and overestimated hemoglobin and hematocrit.

Indexed as

Intensive Care Units, NeonatalPoint-of-Care SystemsPoint-of-Care TestingBlood GlucoseChloridesFemaleHematocritHemoglobinsHumansInfant, NewbornMalePotassiumRetrospective StudiesSodiumBlood GlucoseChloridesHemoglobinsPotassiumSodium

Identifiers

PMID41419656
PMCPMC12865781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.