Evidence map›Paper›PMID 41419614›Full record

ArticleScientific reports2025

Clostridium leptum attenuates allergic airway inflammation via tDC‒Treg axis activation in a murine model of gut dysbiosis-associated asthma.

Heng Ding, Yu Wan, Liang Ma, Shiting Su, Yidong Zhao, Wenjie Mao, Liwen Zhang, Zhiying Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Nutrients · 2026
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heng Ding *Department of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China.
Yu Wan *Department of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China.
Liang Ma *Department of Gastroenterology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Shiting SuDepartment of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China.
Yidong ZhaoDepartment of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China.
Wenjie MaoDepartment of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China.
Liwen ZhangDepartment of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China. zhangliwenlove827@163.com.
Zhiying HuangDepartment of Pediatrics, the Second People's Hospital of Changzhou, the Third Affiliate Hospital of NanJing medical University, Changzhou, Jiangsu, China. hzy982@njmu.edu.cn.

Funding

Changzhou Municipal Science and Technology Bureau Applied Basic Research Program CJ20230067National Natural Science Foundation of China No. 82400025Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01A307The Jiangsu Provincial Health Commission Medical Research Youth Project MQ2024001the Research Project of Changzhou Medical Center, Nanjing Medical University CMCB202301; CMCB202423the Top Talent of Changzhou "The 14th Five-Year Plan" High-Level Health Talents Training Project 2022CZBJ006; 2024BJHB013Youth Science and Technology Project of Changzhou Municipal Health Commission QN202349; QN202348; QN202316
6 · The paper itself

Abstract

Allergic pulmonary inflammation is driven by allergen-specific Th2/Th17 responses counterregulated by tolerogenic dendritic cells (tDCs) and regulatory T cells (Tregs). While early-life colonization with commensal Clostridia induces the generation of colonic Tregs, the therapeutic potential of Clostridium leptum (CL) monotherapy to treat asthma patients with comorbid gut dysbiosis remains unexplored. Therefore, this study aimed to investigate whether 14 days of oral CL administration restores gut-lung immune homeostasis and suppresses allergic inflammation via tDC/Treg induction in a dysbiosis-asthma comorbidity model. To this end, adult BALB/c mice were subjected to ovalbumin (OVA) sensitization/challenge and antibiotic-induced gut dysbiosis. Interventions included 14 days of oral CL (5 × 10

Indexed as

AsthmaClostridiumDendritic CellsDysbiosisT-Lymphocytes, RegulatoryAnimalsBudesonideCytokinesDisease Models, AnimalFemaleGastrointestinal MicrobiomeMiceMice, Inbred BALB COvalbuminBudesonideCytokinesOvalbuminAsthmaClostridium leptumGut microbiotaRegulatory T cellsTolerogenic dendritic cellsTryptophan metabolism

Identifiers

PMID41419614
PMCPMC12816705

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.