Evidence map›Paper›PMID 41419527›Full record

ArticleScientific reports2025

Characteristics of salivary IgA responses to oral microbiota in patients with oral lichen planus.

Yuya Takeda, Nahoko Kato-Kogoe, Shoichi Sakaguchi, Shinsuke Ieda, Yukari Tasaka, Naoki Mizobata, Michi Omori, Wataru Hamada, Shota Nakamura, Takashi Nakano and 2 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yuya TakedaDepartment of Oral and Maxillofacial Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Nahoko Kato-KogoeDepartment of Dentistry and Oral Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki City, Osaka, 569-8686, Japan. nahoko.kogoe@ompu.ac.jp.
Shoichi SakaguchiDepartment of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Shinsuke IedaDepartment of Oral and Maxillofacial Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Yukari TasakaDepartment of Oral and Maxillofacial Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Naoki MizobataDepartment of Oral and Maxillofacial Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan.
Michi OmoriDepartment of Dentistry and Oral Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki City, Osaka, 569-8686, Japan.
Wataru HamadaDepartment of Dentistry and Oral Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki City, Osaka, 569-8686, Japan.
Shota NakamuraDepartment of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Takashi NakanoDepartment of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Takaaki UenoDepartment of Dentistry and Oral Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-Machi, Takatsuki City, Osaka, 569-8686, Japan.
Tatsushi MatsumuraDepartment of Oral and Maxillofacial Surgery, Wakayama Medical University, Kimiidera, Wakayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with a risk of malignant transformation. Oral bacteria are associated with OLP development and progression; however, the immune response, especially the salivary immunoglobulin A (IgA) response to these bacteria remains poorly understood. Therefore, this study aimed to characterize the salivary microbiota in patients with OLP and evaluate the corresponding salivary IgA response. Stimulated saliva samples were collected from 21 patients with OLP and 56 control participants, and 16S rRNA metagenomic analysis was performed to characterize the composition of the microbiota. In addition, IgA-enriched and non-enriched fractions from the saliva samples were separated via magnetic-activated cell sorting, followed by 16S rRNA metagenomic analysis. To evaluate differences in IgA responses to each bacterium between the two groups, we calculated the IgA index. The diversity and bacterial composition of the salivary microbiota differed considerably between the OLP and control groups. Several bacterial genera, including Leptotrichia, Fusobacterium, and Streptococcus, showed markedly lower IgA index in the OLP group than the control group. In conclusion, patients with OLP exhibited a distinctive salivary IgA response to salivary microbiota, suggesting a potential association between OLP and this altered response.

Indexed as

Immunoglobulin AImmunoglobulin A, SecretoryLichen Planus, OralMicrobiotaSalivaAdultAgedBacteriaCase-Control StudiesFemaleHumansMaleMetagenomicsMiddle AgedRNA, Ribosomal, 16SImmunoglobulin AImmunoglobulin A, SecretoryRNA, Ribosomal, 16S16S rRNAIgA-seqImmunoglobulin AMicrobiotaOLPSaliva

Identifiers

PMID41419527
PMCPMC12717238

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