ReviewNPJ breast cancer2025
Exploring KAT6 as a therapeutic target in breast cancer: epigenetic approaches for precision medicine.
Review in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches.Acta crystallographica. Section D, Structural biology · 2026Article
- Post-CDK4/6 inhibitor therapy in HR+/HER2- advanced breast cancer: expanding options and persisting uncertainties.Exploration of targeted anti-tumor therapy · 2026Review
- Artemis: Harnessing Knowledge Graphs for Next-Generation Drug Target Prioritization.Computational and structural biotechnology journal · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is a leading cause of cancer-related mortality among women, with hormone receptor-positive (HR + ) disease representing the majority of cases. Despite advances in targeted therapies and antibody-drug conjugates, resistance to treatment remains a significant challenge, necessitating innovative therapeutic strategies. Epigenetic dysregulation, particularly involving histone acetylation, plays a crucial role in tumorigenesis and therapy resistance. Lysine acetyltransferase 6 (KAT6A/B), key regulators of chromatin structure and gene expression, have emerged as promising therapeutic targets in HR+ breast cancer. This review highlights the molecular mechanisms by which KAT6A/B modulate histone acetylation and gene regulation, emphasizing their roles in oncogenic pathways and cellular processes such as transcriptional activation, chromatin remodeling, and regulation of cellular senescence. We discuss preclinical evidence supporting the therapeutic potential of KAT6 inhibition and the challenges faced in epigenetic drug development, including the need for robust biomarker-driven approaches. Finally, we explore the prospects for integrating KAT6 inhibitors with existing therapies to overcome resistance and improve patient outcomes in breast cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.