ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026
Combining interictal and ictal low-density EEG source imaging to delineate the epileptogenic zone in young children.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Pediatric epilepsy surgery: Global survey of referral and presurgical evaluation practices.Epilepsia · 2026Article
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13 authors.
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Abstract
The aim of this study was to evaluate the feasibility of low-density (LD) interictal (IIC) and ictal (IC) electrical source imaging (ESI), and to assess their individual and combined diagnostic accuracy and predictive value in a cohort of children with drug-resistant epilepsy (DRE) who underwent resective surgery before the age of 7. Retrospective analysis was conducted on de-identified EEG and MRI data, which were (semi)-automatically processed, blinded to clinical information, to compute both IIC and IC-ESI. The concordance of ESI localizations with the resection cavity at sublobar level, and the association with surgical outcome were assessed. Thirty-two children were included. IIC- and IC-ESI showed an accuracy of 66 % (CI 95 % 47-81 %) and 72 % (CI 95 % 53-86 %) and a diagnostic odds ratio (DOR) of 3.0 (CI 95 % 0,66-13,69; p = 0,15) and 5.0 (CI 95 % 0,91-27,47; p = 0,06), respectively. The combined approach increased diagnostic performance, achieving an overall accuracy of 75 % and a DOR of 11.4 (CI 95 % 1.08-120,35; p = 0,042). In multivariate logistic regression analysis, the combined IIC/IC ESI result emerged as the strongest predictor of postsurgical seizure freedom (OR: 222,28; p = 0,0262; AUC: 0.87). These findings demonstrate that combined (semi)-automated LD-IIC and IC-ESI is feasible and can accurately localize the epileptogenic zone and predict postsurgical seizure freedom in children under 7 years of age. ESI may support earlier surgical referral, reduce the time from epilepsy onset to surgery, and ultimately improve long-term outcomes.
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