Observational studyBMJ open2025
Incidence and predictors of intraoperative hypoxaemia and bradycardia in different paediatric age groups in teaching and comprehensive specialised tertiary hospital in resource-constrained setting: a prospective observational cohort study.
Observational study in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
objectiveThe objective of this study was to determine the incidence and predictors of intraoperative hypoxaemia and bradycardia in paediatric patients. STUDY DESIGN AND
settingA single-arm prospective cohort study was conducted, and data collection was carried out from 15 February 2024 to 30 September 2024 at Wachemo University, Nigest Elleni Mohammed Memorial Comprehensive Specialised Hospital.
participantsThe study included all paediatric patients undergoing surgery who had American Society of Anaesthesiologists classes II and III. PRIMARY OUTCOME MEASURES: Incidence and predictors of intraoperative hypoxaemia. SECONDARY OUTCOME MEASURES: Incidence and predictors of intraoperative bradycardia.
resultsThe incidence of intraoperative hypoxaemia was 33.3%. Paediatric age (<1 year), presence of comorbidities, use of muscle relaxants, use of narcotics and duration of surgery (≥1 hour) were predictors of intraoperative hypoxaemia, with p<0.005 and adjusted OR values of 5.3 (2.1-6.1), 4.1 (1.91-5.34), 3.1 (1.1-5.31), 4.01 (2.5-7.1) and 3.2 (1.41-6.1), respectively. However, the type of surgery was not associated with intraoperative hypoxaemia (p=0.081).This study has been conducted in a resource-limited setting and with methodological limitations such as short follow-up period, employing a single-arm cohort design, utilisation of sub-standardised intraoperative vital sign monitoring, proper intraoperative event documentation, over-reporting and under-reporting of the findings. This can cause overestimation of the incidence of hypoxaemia compared with studies conducted in a good resource set-up.
conclusionThe incidence of intraoperative hypoxaemia and bradycardia, which is significantly associated with comorbidities, age (<1 year), use of opioids and muscle relaxants and surgeries lasting >1 hour, is high in paediatric patients who undergo surgery with general anaesthesia. RESEARCH REGISTRATION: Research registration unique identifying number (UIN) 10811 (https://www.researchregistry.com).
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