Evidence map›Paper›PMID 41419211›Full record

ArticleACS chemical biology2026

Synthesis and Biological Evaluation of Colibactin Derivatives.

Yougant Airan, Olga Fedorova, Collin Heer, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Ranjit S Bindra, Seth B Herzon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yougant AiranDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0009-0002-8047-2659
Olga FedorovaDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Collin HeerDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States.
Matthew G ReesBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Melissa M RonanBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Jennifer A RothBroad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.
Ranjit S BindraDepartment of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, United States.
Seth B HerzonDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-5940-9853

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
Structural and functional studies of colibactinR01CA215553 · NCI · YALE UNIVERSITY · PI Seth B. Herzon, Christian Jobin · 2018 to 2026
$5.5M
Elucidating and exploiting NAD metabolic defects in cancerK00CA245722 · NCI · YALE UNIVERSITY · PI HEER, COLLIN DAVID · 2021 to 2024
$378k
High Content Imaging System for Microscopy-Based High-Throughput AssaysS10OD032384 · OD · YALE UNIVERSITY · PI SUROVTSEVA, YULIA · 2022 to 2022
$230k
NCI NIH HHS K00 CA245722NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA215553NIH HHS S10 OD032384
6 · The paper itself

Abstract

Colibactin is a pseudo-

Indexed as

PeptidesPolyketidesEscherichia coliHumanscolibactinPeptidesPolyketides

Identifiers

PMID41419211
PMCPMC12856499

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.