Evidence map›Paper›PMID 41419177›Full record

ArticleEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2026

A Qualitative Study of Clinician Barriers and Facilitators to De-escalation of Thyroid Stimulating Hormone Suppression in Thyroid Cancer Survivors.

Nina Francis-Levin, Chiu Yi Tan, Brittany L Gay, Megan R Haymart, Maria Papaleontiou

Abstract read
In one paragraph

Article in Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Nina Francis-LevinDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan.
Chiu Yi TanSchool of Social Policy & Practice, University of Pennsylvania, Philadelphia, Pennsylvania.
Brittany L GayDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan.
Megan R HaymartDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan.
Maria PapaleontiouDivision of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. Electronic address: mpapaleo@med.umich.edu.

Funding

Optimizing Care for Older Adults through Thyroid Hormone DeprescribingRF1AG079833 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAPALEONTIOU, MARIA · 2025 to 2025
$2.2M
Risk-stratified care for thyroid cancer survivorsR01CA281976 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Megan Rist Haymart · 2024 to 2026
$2.0M
Optimizing Care for Older Adults through Thyroid Hormone DeprescribingR01AG079833 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAPALEONTIOU, MARIA · 2023 to 2024
$1.6M
NCI NIH HHS R01 CA281976NIA NIH HHS R01 AG079833NIA NIH HHS RF1 AG079833
6 · The paper itself

Abstract

objectiveMost patients with differentiated thyroid cancer have low-risk disease and excellent prognosis. Thyroid stimulating hormone (TSH) suppression therapy after initial treatment may be unnecessary and potentially harmful for survivors with recurrence-free, low- or intermediate-risk thyroid cancer. Little is known about clinician-reported barriers and facilitators to reducing thyroid cancer survivors' thyroid hormone dose with the goal of aiming for TSH in the normal reference range.

methodsClinicians from the fields of endocrinology (n = 8) and primary care (n = 7) were recruited through convenience/snowball sampling to participate in semistructured focus groups. Data collection and analyses were informed by the Theoretical Domains Framework for behavior change, a valuable integrative framework which can facilitate comprehensive assessment of behavioral determinants in qualitative studies. Deductive coding and inductive thematic analysis were conducted.

resultsParticipants were majority female (73%) and averaged 14 years in clinical practice (range, 1-22). Barriers and facilitators emerged at the patient-level, clinician-level, and system-level. Key clinician-reported barriers included patient distress/anxiety and misinformation, unclear shared patient survivorship goals and plans between specialties, and clinic visit time constraints. Clinician-reported facilitators included building a trusting relationship, delivery of patient-centered education, and communication and collaboration between specialties to establish shared long-term survivorship plans.

conclusionsWe identified barriers and facilitators to de-escalating TSH suppression therapy in thyroid cancer survivors at multiple levels. Understanding these factors will enable clinicians to provide high-value, patient-centered care in order to reduce overtreatment, patient harm and improve quality of life in thyroid cancer survivors.

Indexed as

Cancer SurvivorsThyroid NeoplasmsThyrotropinAdultFemaleFocus GroupsHumansMaleMiddle AgedQualitative ResearchThyrotropinde-escalationsurvivorshipthyroid cancerthyroid hormoneTSH suppression

Identifiers

PMID41419177
PMCPMC13325194

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